Gómez-González, BelénBarroso, SoniaHerrera-Moyano, EmiliaAguilera, Andrés2023-02-082023-02-082020-02-16http://hdl.handle.net/10668/15116A large body of research supports that transcription plays a major role among the many sources of replicative stress contributing to genome instability. It is therefore not surprising that the DNA damage response has a role in the prevention of transcription-induced threatening events such as the formation of DNA-RNA hybrids, as we have recently found through an siRNA screening. Three major DDR pathways were defined to participate in the protection against DNA-RNA hybrids: ATM/CHK2, ATR/CHK1 and Postreplication Repair (PRR). Based on these observations, we envision different scenarios of DNA-RNA hybridization and their consequent DNA damage.enDNA damage responseDNA-RNA hybridsgenetic instabilitypostreplication repairreplicative stressAnimalsAtaxia Telangiectasia Mutated ProteinsBase PairingCell CycleCheckpoint Kinase 1DNA DamageDNA RepairDNA ReplicationDNA, Single-StrandedHumansRNAresearch article32065022open access10.1080/15384101.2020.17280151551-4005PMC7145327https://www.tandfonline.com/doi/pdf/10.1080/15384101.2020.1728015?needAccess=truehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145327/pdf