Gordillo Hernández, AlejandraDominguez-Adame Lanuza, EduardoCano Matias, AuxiliadoraPerez Huertas, RosarioGallardo Rodriguez, Katherine MariaGallinato Perez, PurificacionOliva Mompean, Fernando2015-12-042015-12-042015-08-27Hernández AG, Lanuza ED, Matias AC, Huertas RP, Rodriguez KM, Perez PG, et al. Large gangliocytic paraganglioma of the duodenum: A rare entity. World J Gastrointest Surg. 2015; 7(8):170-3http://hdl.handle.net/10668/2105Journal Article;Gangliocytic paragangliomas are rare tumors that almost exclusively occur within the second portion of the duodenum. Although these tumors generally have a benign clinical course, they have the potential to recur or metastasize to regional lymph nodes. The case report presented here describes a 57-year-old female patient with melena, progressive asthenia, anemia, and a mass in the second-third portion of the duodenum that was treated by local excision. The patient was diagnosed with a friable bleeding tumor. The histologic analysis showed that the tumor was a 4 cm gangliocytic paraganglioma without a malignant cell pattern. In the absence of local invasion or distant metastasis, endoscopic resection represents a feasible, curative therapy. Although endoscopic polypectomy is currently considered the treatment of choice, it is not recommended if the size of the tumor is > 3 cm and/or there is active or recent bleeding. Patients diagnosed with a gangliocytic paraganglioma should be closely followed-up for possible local recurrence.enDuodenumGangliocytic paragangliomaGanglion cellsAsteniaGanglios linfáticosRecurrencia local de neoplasiaParagangliomaMedical Subject Headings::Diseases::Hemic and Lymphatic Diseases::Hematologic Diseases::AnemiaMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::AstheniaMedical Subject Headings::Anatomy::Digestive System::Gastrointestinal Tract::Intestines::Intestine, Small::DuodenumMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Anatomy::Tissues::Lymphoid Tissue::Lymph NodesMedical Subject Headings::Anatomy::Fluids and Secretions::Feces::MelenaMedical Subject Headings::Diseases::Neoplasms::Neoplastic Processes::Neoplasm Recurrence, LocalMedical Subject Headings::Diseases::NeoplasmsMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Germ Cell and Embryonal::Neuroectodermal Tumors::Neuroendocrine Tumors::Paragangliomaresearch article26328037open access10.4240/wjgs.v7.i8.1701948-9366PMC4550844