CD34+ Cell Selection versus Reduced-Intensity Conditioning and Unmodified Grafts for Allogeneic Hematopoietic Cell Transplantation in Patients Age >50 Years with Acute Myelogenous Leukemia and Myelodysplastic Syndrome .

Barba, PereMartino, RodrigoZhou, QinCho, ChristinaCastro-Malaspina, HugoDevlin, SeanEsquirol, AlbertGiralt, SergioJakubowski, Ann ACaballero, DoloresMaloy, MollyPapadopoulos, Esperanza BPiñana, José LuísFox, María LauraMárquez-Malaver, Francisco JValcárcel, DavidSolano, CarlosLópez-Corral, LucíaSierra, JorgePerales, Miguel-Angel2023-01-252023-01-252018-01-02http://hdl.handle.net/10668/11972Reduced-intensity conditioning (RIC) and T cell depletion (TCD) through CD34+ cell selection without the use of post-transplantation immunosuppression are 2 strategies used to reduce nonrelapse mortality (NRM) in older patients after allogeneic hematopoietic cell transplantation (allo-HCT). To compare the efficacy of the RIC and TCD approaches, we evaluated the outcomes of patients age >50 years with acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) who underwent allo-HCT from an HLA-matched donor with one of these strategies. Baseline characteristics were comparable in the patients receiving TCD (n = 204) and those receiving RIC (n = 151), except for a higher proportion of unrelated donors (68% versus 40%; P 50 years with acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) who underwent allo-HCT from an HLA-matched donor with one of these strategies. Baseline characteristics were comparable in the patients receiving TCD (n = 204) and those receiving RIC (n = 151), except for a higher proportion of unrelated donors (68% versus 40%; P 50 years with AML and MDS.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Allogeneic hematopoietic cell transplantationGVHDRICT cell depletionAgedAntigens, CD34FemaleGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansLeukemia, Myeloid, AcuteLymphocyte DepletionMaleMiddle AgedMyeloablative AgonistsMyelodysplastic SyndromesRecurrenceRetrospective StudiesTransplantation ConditioningTransplantation, HomologousCD34+ Cell Selection versus Reduced-Intensity Conditioning and Unmodified Grafts for Allogeneic Hematopoietic Cell Transplantation in Patients Age >50 Years with Acute Myelogenous Leukemia and Myelodysplastic Syndrome .research article29305194open access10.1016/j.bbmt.2017.12.8041523-6536PMC6800017http://www.bbmt.org/article/S1083879117318396/pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800017/pdf