Bogas, GPerez-Sanchez, NAndreu, IDoña, IPerkins, J RBlanca, MCanto, GCornejo-Garcia, J ABlanca-Lopez, N2023-01-252023-01-252016Bogas G, Pérez-Sánchez N, Andreu I, Doña I, Perkins JR, Blanca M, et al. Anaphylaxis to 2 NSAIDs in a Patient Who Tolerated ASA. J Investig Allergol Clin Immunol. 2016;26(4):266-81018-9068http://hdl.handle.net/10668/10312Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most frequent cause of drug hypersensitivity [1]. NSAID-induced reactions can be classified into 5 categories: (1) NSAID-exacerbated respiratory disease (NERD); (2) NSAID-exacerbated cutaneous disease (NECD); (3) NSAID-induced urticaria and/or angioedema (NIUA); (4) single NSAID-induced urticaria/angioedema/anaphylaxis (SNIUAA); and (5) single NSAID-induced delayed hypersensitivity reactions (SNIDR) [2]. Patients in the first 3 categories react to NSAIDs from various chemical groups in a nonallergic type of drug hypersensitivity known as cross-intolerance. The mechanism involved in these reactions is thought to be related to an imbalance in the arachidonic acid metabolic pathway leading to increased release of cysteinyl leukotrienes.enASA toleranceAnaphylaxisCross-intoleranceNSAID hypersensitivitySelective reactionsHipersensibilidad a AINEIntolerancia cruzadaReacciones selectivasAnafilaxiaTolerancia a AASAnaphylaxisAnti-Inflammatory Agents, Non-SteroidalAspirinHumansMaleMiddle Agedresearch article27470646Restricted accessAntiinflamatorios no esteroideosUrticariaHipersensibilidad a las drogasAngioedemaLeucotrienosÁcido araquidónico10.18176/jiaci.0066http://www.jiaci.org/revistas/vol26issue4_7_2.pdf