Clinical-pathological characteristics and short-term follow-up associated with proliferation, apoptosis and angiogenesis in a prospective cohort of patients with colorectal tumours.

Redondo, MaximinoAbitei, CristinaTéllez, TeresaFúnez, RafaelPereda, TeresaRodrigo, IsabelBetancourt, Ana MGarcía-Aranda, MarilinaRueda, AntonioMartínez García, Rafael CayetanoMorales Suarez-Varela, María ManuelaZabalza, IñakiSánchez Del Charco, MatildeBorrero Martín, Juan JoséGarcía Del Moral, RaimundoEscobar, AntonioQuintana, JoséMaríaRivas-Ruiz, FranciscoREDISSEC-CARESS/CCR group2025-01-072025-01-072019https://hdl.handle.net/10668/26902We investigate the clinical and pathological features related to variations in colorectal tumour apoptosis, proliferation and angiogenesis and the influence of the latter in short-term mortality (2 years); 551 tumour samples from a prospective cohort of patients with colorectal cancer were examined and tumour biology markers were determined as follows: percentage of apoptotic cells, by the terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling technique; Ki-67 antigen, as a cell proliferation marker and density of microvessels (as a marker of angiogenesis). An increase in the percentage of cellular apoptosis is significantly related to the presence of poorly differentiated tumours, with vascular invasion (p enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/Cell proliferationKi-67 markerangiogenesisapoptosiscolorectal neoplasmsAdultAgedApoptosisBiomarkers, TumorCell ProliferationColorectal NeoplasmsDisease-Free SurvivalEndoglinFemaleFollow-Up StudiesHumansKi-67 AntigenMaleMiddle AgedNeovascularization, PathologicPrognosisClinical-pathological characteristics and short-term follow-up associated with proliferation, apoptosis and angiogenesis in a prospective cohort of patients with colorectal tumours.research article30957671open access10.1177/10104283198356841423-0380https://journals.sagepub.com/doi/pdf/10.1177/1010428319835684