Calle Rubio, MyriamSoriano, Joan BLópez-Campos, José LuisSoler-Cataluña, Juan JAlcázar Navarrete, BernardinoRodríguez González-Moro, José MiguelMiravitlles, MarcBarrecheguren, MiriamFuentes Ferrer, Manuel ERodriguez Hermosa, Juan LuisEPOCONSUL Study2023-01-252023-01-252018-06-28http://hdl.handle.net/10668/12652Alpha-1 antitrypsin deficiency (AATD) is the most common hereditary disorder in adults, but is under-recognized. In Spain, the number of patients diagnosed with AATD is much lower than expected according to epidemiologic studies. The objectives of this study were to assess the frequency and determinants of testing serum α1-antitrypsin (AAT) levels in COPD patients, and to describe factors associated with testing. EPOCONSUL is a cross-sectional clinical audit, recruiting consecutive COPD cases over one year. The study evaluated serum AAT level determination in COPD patients and associations between individual, disease-related, and hospital characteristics. A total of 4,405 clinical records for COPD patients from 57 Spanish hospitals were evaluated. Only 995 (22.5%) patients had serum AAT tested on some occasion. A number of patient characteristics (being male [OR 0.5, p Testing of AAT blood levels in COPD patients treated at outpatient respiratory clinics in Spain is infrequent. However, when tested, AATD (based on the serum AAT levels ≤100 mg/dL) is detected in one in five COPD patients. Efforts to optimize AATD case detection in COPD are needed.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/AgedAmbulatory CareClinical AuditCross-Sectional StudiesFemaleHumansMaleMiddle AgedPulmonary Disease, Chronic ObstructiveSpainalpha 1-Antitrypsinalpha 1-Antitrypsin Deficiencyresearch article29953442open access10.1371/journal.pone.01987771932-6203PMC6023216https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0198777&type=printablehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023216/pdf