Bandres-Ciga, SaraPrice, Timothy RyanBarrero, Francisco JavierEscamilla-Sevilla, FranciscoPelegrina, JavierArepalli, SampathHernandez, DenaGutierrez, BlancaCervilla, JorgeRivera, MargaritaRivera, AlbertoDing, Jing-huiVives, FranciscoNalls, MichaelSingleton, AndrewDuran, Raquel2023-02-122023-02-122016-09-010197-4580http://hdl.handle.net/10668/18845Here, we set out to study the genetic architecture of Parkinson's disease (PD) through a Genome-Wide Association Study in a Southern Spanish population. About 240 PD cases and 192 controls were geno-typed on the NeuroX array. We estimated genetic variation associated with PD risk and age at onset (AAO). Risk profile analyses for PD and AAO were performed using a weighted genetic risk score. Total heritability was estimated by genome-wide complex trait analysis. Rare variants were screened with single-variant and burden tests. We also screened for variation in known PD genes. Finally, we explored runs of homozygosity and structural genomic variations. We replicate PD association (uncorrected p-valueenParkinson's diseaseGeneticsGWASSouthern SpainRisk lociGenetic riskMutationsAssociationMetaanalysisAgeIdentificationVariantsComplexRegionresearch articleopen access10.1016/j.neurobiolaging.2016.06.0011558-1497https://europepmc.org/articles/pmc4976046?pdf=render381092900026