Arroyo, DavidBetriu, AngelsValls, JoanGorriz, Jose LPallares, VicenteAbajo, MariaGracia, MartaValdivielso, Jose ManuelFernandez, ElviraInvestigators from the NEFRONA study2025-01-072025-01-072017https://hdl.handle.net/10668/24969The ankle-brachial index (ABI) is widely used to diagnose subclinical peripheral artery disease (PAD) in the general population, but data assessing its prevalence and related factors in different chronic kidney disease (CKD) stages are scarce. The aim of this study is to evaluate the prevalence and associated factors of pathological ABI values in CKD patients. NEFRONA is a multicentre prospective project that included 2445 CKD patients from 81 centres and 559 non-CKD subjects from 9 primary care centres across Spain. A trained team collected clinical and laboratory data, performed vascular ultrasounds and measured the ABI. PAD prevalence was higher in CKD than in controls (28.0 versus 12.3%, P Asymptomatic PAD is very prevalent in all CKD stages, but factors related to a low or high pathological ABI differ, revealing different pathogenic pathways. Diabetes, dyslipidaemia, inflammation and mineral-bone disorders play a role in the appearance of PAD in CKD.enankle-brachial indexatheromatosiscardiovascular riskchronic kidney diseaseperipheral artery diseaseAgedAnkle Brachial IndexC-Reactive ProteinCarotid Intima-Media ThicknessCholesterol, LDLCohort StudiesDiabetes MellitusFemaleHumansKidney Failure, ChronicMaleMiddle AgedPeripheral Arterial DiseasePrevalenceProspective StudiesRenal DialysisRenal Insufficiency, ChronicRisk FactorsSeverity of Illness IndexSpainTriglyceridesVitamin Dresearch article27190385open access10.1093/ndt/gfw0391460-2385https://academic.oup.com/ndt/article-pdf/32/3/513/17822387/gfw039.pdf