Melguizo-Rodriguez, LuciaRamos-Torrecillas, JavierManzano-Moreno, Francisco JavierIllescas-Montes, RebecaRivas, AnaRuiz, ConcepcionDe Luna-Bertos, ElviraGarcia-Martinez, Olga2023-01-252023-01-252018-04-13Melguizo-Rodríguez L, Ramos-Torrecillas J, Manzano-Moreno FJ, Illescas-Montes R, Rivas A, Ruiz C, et al. Effect of phenolic extracts from different extra-virgin olive oil varieties on osteoblast-like cells. PLoS One. 2018 Apr 26;13(4):e0196530.http://hdl.handle.net/10668/12400The reported incidence of osteoporosis is lower in countries in which the Mediterranean diet predominates, and this apparent relationship may be mediated by the phenolic compounds present in olive oil. The objective of this study was to determine the effect of phenolic extracts from different varieties of extra-virgin olive oil (Picual, Arbequina, Picudo, and Hojiblanca) on the differentiation, antigenic expression, and phagocytic capacity of osteoblast-like MG-63 cells. At 24 h of treatment a significant increase in phosphatase alkaline activity and significant reductions in CD54, CD80, and HLA-DR expression and in phagocytic activity were observed in comparison to untreated controls. The in vitro study performed has demonstrated that phenolic compounds from different extra virgin olive oil varieties can modulate different parameters related to osteoblast differentiation and function.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/HLA-DR AntigensOleaPhenolsAlkaline PhosphataseCell LineHumansIntercellular Adhesion Molecule-1OsteoblastsPhagocytosisPlant Extractsresearch article29698527open accessExtractos vegetalesFagocitosisFosfatasa alcalinaHumanosLínea celularMolécula 1 de adhesión intercelularOsteoblastos10.1371/journal.pone.01965301932-6203PMC5919649https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0196530&type=printablehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919649/pdf