Mariosa, DanielaSmith-Byrne, KarlRichardson, Tom GFerrari, PietroGunter, Marc JPapadimitriou, NikosMurphy, NeilChristakoudi, SofiaTsilidis, Konstantinos KRiboli, ElioMuller, DavidPurdue, Mark PChanock, Stephen JHung, Rayjean JAmos, Christopher IO'Mara, Tracy AAmiano, PilarPasanisi, FabrizioRodriguez-Barranco, MiguelKrogh, VittorioTjønneland, AnneHalkjær, JyttePerez-Cornago, AuroraChirlaque, María-DoloresSkeie, GuriRylander, CharlottaBorch, Kristin BenjaminsenAune, DagfinnHeath, Alicia KWard, Heather ASchulze, MatthiasBonet, CatalinaWeiderpass, ElisabeteDavey Smith, GeorgeBrennan, PaulJohansson, Mattias2023-05-032023-05-032022-03-16Mariosa D, Smith-Byrne K, Richardson TG, Ferrari P, Gunter MJ, Papadimitriou N, et al. Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study. J Natl Cancer Inst. 2022 Sep 9;114(9):1296-1300.http://hdl.handle.net/10668/19809It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for 6 obesity-related cancers, we performed univariable and multivariable analyses using 1) Mendelian randomization (MR) analysis and 2) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger early life body size was associated with higher risk of endometrial (odds ratioMR = 1.61, 95% confidence interval = 1.23 to 2.11) and kidney (odds ratioMR = 1.40, 95% confidence interval = 1.09 to 1.80) cancer. These associations were attenuated after accounting for adult body size in both the MR and cohort analyses. Early life body mass index (BMI) was not consistently associated with the other investigated cancers. The lack of clear independent risk associations suggests that early life BMI influences endometrial and kidney cancer risk mainly through pathways that are common with adult BMI.enAttribution 3.0 Intergovernmental Organization.(https://creativecommons.org/licenses/by/3.0/igo/obesitybody mass index procedurecancerrenal cancerattenuationcancer riskkidneyAdultBody Mass IndexBody SizeCohort StudiesGenome-Wide Association StudyHumansMendelian Randomization AnalysisNeoplasmsObesityProspective Studiesresearch article35438160open accessAdultoAnálisis de la aleatorización MendelianaEstudio de asociación del genoma completoEstudios prospectivosEstudios de cohortesHumanosNeoplasiasObesidadTamaño corporalÍndice de masa corporal10.1093/jnci/djac0611460-2105PMC9468294https://academic.oup.com/jnci/article-pdf/114/9/1296/45751642/djac061.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468294/pdf