Sola-Rodríguez, SergioVargas-Hitos, José AntonioGavilán-Carrera, BlancaRosales-Castillo, AntonioSabio, José MarioHernández-Martínez, AlbaMartínez-Rosales, ElenaOrtego-Centeno, NorbertoSoriano-Maldonado, Alberto2023-02-092023-02-092021-04-27http://hdl.handle.net/10668/17724This study aimed to examine the association of relative handgrip strength (rHGS) with cardiometabolic disease risk factors in women with systemic lupus erythematosus (SLE). Seventy-seven women with SLE (mean age 43.2, SD 13.8) and clinical stability during the previous six months were included. Handgrip strength was assessed with a digital dynamometer and rHGS was defined as absolute handgrip strength (aHGS) divided by body mass index (BMI). We measured blood pressure, markers of lipid and glucose metabolism, inflammation (high sensitivity C-reactive protein [hs-CRP]), arterial stiffness (pulse wave velocity [PWV]), and renal function. A clustered cardiometabolic risk index (z-score) was computed. Pearson's bivariate correlations revealed that higher rHGS was associated with lower systolic blood pressure (SBP), triglycerides, hs-CRP, PWV, and lower clustered cardiometabolic risk (rrange = from -0.43 to -0.23; all p The findings suggest that higher rHGS is significantly associated with lower cardiometabolic risk in women with SLE.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/autoimmune diseasebody mass indexcardiovascular diseasecardiovascular risklupusmetabolismmuscle strengthrisk factorsAdultCardiovascular DiseasesCross-Sectional StudiesFemaleHand StrengthHumansLupus Erythematosus, SystemicPulse Wave AnalysisRisk Factorsresearch article33925420open access10.3390/ijerph180946301660-4601PMC8123887https://www.mdpi.com/1660-4601/18/9/4630/pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123887/pdf