Javaheri, ShahrokhCampos-Rodriguez, FranciscoMartinez-Garcia, Miguel Angel2023-02-082023-02-082020Javaheri S, Campos-Rodriguez F, Martinez-Garcia MA. Response. Chest. 2020 Apr;157(4):1047-1048http://hdl.handle.net/10668/15329We read with interest the letter from Singh et al proposing a two-stage propensity score PS analysis as an alternative method to include sleepy patients in a trial that explores the relation between CPAP treatment and the prevention of cardiovascular diseases In our commentary 1 we only addressed the topic of randomized controlled trials RCTs with the aim of providing potentially useful suggestions to conduct future trials to overcome the challenges that RCTs involve We deliberately did not focus on observational trials or those using PS analysisenContinuous positive airway pressurePropensity score analysisRandomized controlled trialCardiovascular diseaseSleep apnea, obstructiveObservational studyContinuous Positive Airway PressurePropensity ScoreRandomized Controlled TrialCardiovascular DiseasesSleep Apnea, ObstructiveObservational Studyletter32252917Restricted AccessPresión positiva continua en la vía aéreaAnálisis por puntaje de propensiónEnsayo clínico aleatorizadoEnfermedad cardiovascularApnea obstructiva del sueñoEstudio observacional10.1016/j.chest.2019.12.0361931-3543http://journal.chestnet.org/article/S0012369220301240/pdf