Alvarez-Zaballos, SaraGonzalez-Ramallo, VictorQuintana, EduardMuñoz, Patriciade-la-Villa-Martínez, SofiaFariñas, M CarmenArnaiz-de-Las-Revillas, Franciscode-Alarcon, AristidesRodriguez-Esteban, M AngelesMiro, Jose MGoenaga, Miguel AngelGoikoetxea-Agirre, JosuneGarcia-Vazquez, ElisaBoix-Palop, LuciaMartinez-Selles, Manuel2023-05-032023-05-032022-08-13Álvarez-Zaballos S, González-Ramallo V, Quintana E, Muñoz P, de la Villa-Martínez S, Fariñas MC, et al. Multivalvular Endocarditis: A Rare Condition with Poor Prognosis. J Clin Med. 2022 Aug 13;11(16):4736.2077-0383http://hdl.handle.net/10668/21333Background. Infective endocarditis (IE) is a severe condition. Our aim was to describe the profile and prognosis of patients with multivalvular infective endocarditis (MIE) and compare them to single-valve IE (SIE). Methods . We used a retrospective analysis of the Spanish IE Registry (2008–2020). Results. From 4064 definite cases of valvular IE, 577 (14.2%) had MIE. In patients with MIE, the most common locations were mitral (552, 95.7%) and aortic (550, 95.3%), with mitral-aortic involvement present in 507 patients (87.9%). The most common etiologies were S. viridans (192, 33.3%) and S. aureus (113, 19.6%). MIE involved only native valves in 450 patients (78.0%). Compared with patients with SIE, patients with MIE had a similar age (69 vs. 67 years, respectively, p = 0.27) and similar baseline characteristics, but were more frequently men (67.1% vs. 72.9%, p = 0.005) and had a higher incidence of intracardiac complications (36.2% vs. 50.4%, p < 0.001), heart failure (42.7% vs. 52.9%, p < 0.001), surgical indication (67.7 vs. 85.1%, p < 0.001), surgery (46.3% vs. 56.3%), and in-hospital mortality (26.9% vs. 34.3%, p < 0.001). MIE was an independent predictor of in-hospital mortality ( odds ratio (OR) 1.3, 95% confidence interval (CI) 1.1–1.7, p = 0.004) but did not have an independent association with 1-year mortality (OR 1.1, 95% CI 0.9–1.4, p = 0.43). Conclusions. About one-seventh of the valvular IE patients had MIE, mainly due to mitral-aortic involvement. MIE is associated with a poor in- hospital prognosis . An early diagnosis and treatment of IE might avoid its spread to a second valve.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/infective endocarditismortalitymultivalvular endocarditisprognosisMethicillin-Resistant Staphylococcus aureusHospital MortalityRetrospective StudiesConfidence IntervalsEndocarditisHeart FailureEarly Diagnosisresearch article36012974open accessEndocarditisPronósticoInsuficiencia cardíacaMortalidadCirugía generalMétodosIncidencia10.3390/jcm11164736PMC9410199https://www.mdpi.com/2077-0383/11/16/4736/pdf?version=1660532217https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410199/pdf