Álvarez-Zaballos, SaraGonzález-Ramallo, VictorQuintana, EduardMuñoz, Patriciade la Villa-Martínez, SofíaFariñas, M CarmenArnáiz-de Las Revillas, Franciscode Alarcón, ArístidesRodríguez-Esteban, M ÁngelesMiró, José MGoenaga, Miguel AngelGoikoetxea-Agirre, JosuneGarcía-Vázquez, ElisaBoix-Palop, LucíaMartínez-Sellés, ManuelOn Behalf Of Games,2023-05-032023-05-032022-08-132077-0383http://hdl.handle.net/10668/21333Background. Infective endocarditis (IE) is a severe condition. Our aim was to describe the profile and prognosis of patients with multivalvular infective endocarditis (MIE) and compare them to single-valve IE (SIE). Methods. We used a retrospective analysis of the Spanish IE Registry (2008−2020). Results. From 4064 definite cases of valvular IE, 577 (14.2%) had MIE. In patients with MIE, the most common locations were mitral (552, 95.7%) and aortic (550, 95.3%), with mitral-aortic involvement present in 507 patients (87.9%). The most common etiologies were S. viridans (192, 33.3%) and S. aureus (113, 19.6%). MIE involved only native valves in 450 patients (78.0%). Compared with patients with SIE, patients with MIE had a similar age (69 vs. 67 years, respectively, p = 0.27) and similar baseline characteristics, but were more frequently men (67.1% vs. 72.9%, p = 0.005) and had a higher incidence of intracardiac complications (36.2% vs. 50.4%, penAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/infective endocarditismortalitymultivalvular endocarditisprognosisresearch article36012974open access10.3390/jcm11164736PMC9410199https://www.mdpi.com/2077-0383/11/16/4736/pdf?version=1660532217https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410199/pdf