Evaluation of the Bioavailability and Metabolism of Nitroderivatives of Hydroxytyrosol Using Caco-2 and HepG2 Human Cell Models.

Gallardo, ElenaSarria, BeatrizEspartero, José LuisGonzalez Correa, José AntonioBravo-Clemente, LauraMateos, Raquel2023-01-252023-01-252016-03-10http://hdl.handle.net/10668/9867Considering that nitrocatechols present putative effects against Parkinson's disease, the absorption and metabolism of nitroderivatives of hydroxytyrosol (HT) were assessed using human cell model systems. The test compounds nitrohydroxytyrosol (NO2HT), nitrohydroxytyrosyl acetate (NO2HT-A), and ethyl nitrohydroxytyrosyl ether (NO2HT-E) were efficiently transferred across human Caco-2 cell monolayers as an intestinal barrier model, NO2HT-A and NO2HT-E being better (penParkinson’s diseasebioavailabilityhydroxytyrosolmetabolismnitrocatecholsBiological AvailabilityCaco-2 CellsHep G2 CellsHumansHydrolysisIntestinal MucosaLiverModels, BiologicalNitro CompoundsPhenylethyl AlcoholEvaluation of the Bioavailability and Metabolism of Nitroderivatives of Hydroxytyrosol Using Caco-2 and HepG2 Human Cell Models.research article26915652open access10.1021/acs.jafc.6b004011520-5118https://digital.csic.es/bitstream/10261/171540/4/evaluatG2.pdf