Gomez-Samblas, MBernal, DBolado-Ortiz, AVilchez, SBolás-Fernández, FEspino, A MTrelis, MOsuna, A2023-01-252023-01-252018-05-17http://hdl.handle.net/10668/12484Previous studies have established that an increased Th-9 response creates a hostile environment for nematode parasites. Given that IL-23, a cytokine required for maintenance of the IL-17-secreting phenotype, has inhibitory effects on IL-9 production, we hypothesized that reducing circulating IL-23 by treatment with anti-IL-23 antibodies would reduce the establishment and development of parasitic intestinal nematodes. In this study, we show that animals treated with anti-IL-23 monoclonal antibodies showed a drastic reduction in the number of mouse pinworms (Aspiculuris tetraptera) recovered from the intestine (p enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/AnimalsAntibodies, MonoclonalInjections, IntraperitonealInterleukin-23InterleukinsIntestinesMaleMiceMice, Inbred ICRNematode InfectionsParasite Loadresearch article29773890open access10.1038/s41598-018-26194-x2045-2322PMC5958071https://www.nature.com/articles/s41598-018-26194-x.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958071/pdf