Oral Immunotherapy for Food Allergy: A Spanish Guideline. Immunotherapy Egg and Milk Spanish Guide (ITEMS Guide). Part I: Cow Milk and Egg Oral Immunotherapy: Introduction, Methodology, Rationale, Current State, Indications, Contraindications, and Oral Immunotherapy Build-up Phase.

Martorell, AAlonso, EEcheverria, LEscudero, CGarcia-Rodriguez, RBlasco, CBone, JBorja-Segade, JBracamonte, TClaver, ACorzo, J LDe-la-Hoz, BDel-Olmo, RDominguez, OFuentes-Aparicio, VGuallar, ILarramona, HMartin-Muñoz, FMatheu, VMichavila, AOjeda, IOjeda, PPiquer, MPoza, PReche, MRodriguez-Del-Rio, PRodriguez, MRuano, FSanchez-Garcia, STerrados, SValdesoiro, LVazquez-Ortiz, M2023-01-252023-01-252017-06-06Martorell A, Alonso E, Echeverría L, Escudero C, García-Rodríguez R, Blasco C, et al. Oral Immunotherapy for Food Allergy: A Spanish Guideline. Immunotherapy Egg and Milk Spanish Guide (ITEMS Guide). Part I: Cow Milk and Egg Oral Immunotherapy: Introduction, Methodology, Rationale, Current State, Indications, Contraindications, and Oral Immunotherapy Build-up Phase. J Investig Allergol Clin Immunol. 2017;27(4):225-2371018-9068http://hdl.handle.net/10668/11427Cow milk and egg are the most frequent causes of food allergy in the first years of life. Oral immunotherapy (OIT) has been investigated as an alternative to avoidance diets. No clinical practice guidelines on the management of OIT with milk and egg are currently available. Objectives: To develop clinical guidelines for OIT based on available scientific evidence and the opinions of experts. A review was made of studies published between 1984 and June 2016, doctoral theses published in Spain, summaries of communications at scientific meetings (SEAIC, SEICAP, EAACI, and AAAAI), and the consensus of opinion established by a group of experts from the scientific societies SEICAP and SEAIC. Recommendations were established regarding the indications, requirements and practical aspects of the different phases of OIT, as well as special protocols for patients at high risk of adverse reactions. Clinical practice guidelines based on the consensus reached between Spanish experts are presented for the management of OIT with milk and egg.Introducción: El huevo y la leche de vaca son la causa más frecuente de alergia alimentaria en los primeros años de vida. Como alternativa terapéutica a la dieta de eliminación se han investigado otras formas de tratamiento como la inmunoterapia oral (ITO). Actualmente no existen guías de práctica clínica para el manejo de la ITO con leche y huevo. Objetivos: Elaborar una guía clínica para el tratamiento con ITO basada en la evidencia científica disponible y en la opinión de expertos. Métodos: Revisión de estudios publicados desde el año 1984 hasta junio de 2016, tesis doctorales publicadas en España, resúmenes de comunicaciones en congresos (SEAIC, SEICAP, EAACI, AAAAI) y consenso de opinión de un grupo de expertos de las sociedades científicas SEICAP y SEAIC. Resultados: Se establecen recomendaciones acerca de la indicación, requerimientos, aspectos prácticos del tratamiento en las diferentes fases de la ITO, y pautas especiales para pacientes de alto riesgo de reacciones adversas. Conclusiones: Se presenta una guía con las directrices para el manejo en la práctica clínica de la ITO con leche y huevo que aúna la opinión consensuada de expertos españoles.enDesensitizationEgg allergyGuideMilk allergyOmalizumabOral immunotherapySpecific oral tolerance inductionSublingual immunotherapyGuíaInmunoterapia oralDesensibilizaciónInducción de tolerancia oral específicaAlergia a lecheAlergia a huevoInmunoterapia sublingualAdministration, OralAllergensDesensitization, ImmunologicEgg HypersensitivityHumansMilk HypersensitivityPractice Guidelines as TopicSpainOral Immunotherapy for Food Allergy: A Spanish Guideline. Immunotherapy Egg and Milk Spanish Guide (ITEMS Guide). Part I: Cow Milk and Egg Oral Immunotherapy: Introduction, Methodology, Rationale, Current State, Indications, Contraindications, and Oral Immunotherapy Build-up Phase.research article28731411Restricted AccessÓvuloLecheConsensoEspañaHipersensibilidad a los alimentosGuía de práctica clínica10.18176/jiaci.0177http://www.jiaci.org/revistas/10.18176_jiaci.0177_supplementaryappendix1.pdf