Oral Immunotherapy for Food Allergy: A Spanish Guideline. Immunotherapy Egg and Milk Spanish Guide (ITEMS Guide). Part I: Cow Milk and Egg Oral Immunotherapy: Introduction, Methodology, Rationale, Current State, Indications, Contraindications, and Oral Immunotherapy Build-up Phase.

Martorell, AAlonso, EEcheverría, LEscudero, CGarcía-Rodríguez, RBlasco, CBone, JBorja-Segade, JBracamonte, TClaver, ACorzo, J LDe la Hoz, BDel Olmo, RDominguez, OFuentes-Aparicio, VGuallar, ILarramona, HMartín-Muñoz, FMatheu, VMichavila, AOjeda, IOjeda, PPiquer, MPoza, PReche, MRodríguez Del Río, PRodríguez, MRuano, FSánchez-García, STerrados, SValdesoiro, LVazquez-Ortiz, MExpert panel selected from members of the Spanish Society of Pediatric Allergology, Asthma and Clinical Immunology (SEICAP) and the Spanish Society of Allergology and Clinical Immunology (SEAIC)2023-01-252023-01-2520171018-9068http://hdl.handle.net/10668/11427Cow milk and egg are the most frequent causes of food allergy in the first years of life. Oral immunotherapy (OIT) has been investigated as an alternative to avoidance diets. No clinical practice guidelines on the management of OIT with milk and egg are currently available. Objectives: To develop clinical guidelines for OIT based on available scientific evidence and the opinions of experts. A review was made of studies published between 1984 and June 2016, doctoral theses published in Spain, summaries of communications at scientific meetings (SEAIC, SEICAP, EAACI, and AAAAI), and the consensus of opinion established by a group of experts from the scientific societies SEICAP and SEAIC. Recommendations were established regarding the indications, requirements and practical aspects of the different phases of OIT, as well as special protocols for patients at high risk of adverse reactions. Clinical practice guidelines based on the consensus reached between Spanish experts are presented for the management of OIT with milk and egg.enDesensitizationEgg allergyGuideMilk allergyOmalizumabOral immunotherapySpecific oral tolerance inductionSublingual immunotherapyAdministration, OralAllergensDesensitization, ImmunologicEgg HypersensitivityHumansMilk HypersensitivityPractice Guidelines as TopicSpainOral Immunotherapy for Food Allergy: A Spanish Guideline. Immunotherapy Egg and Milk Spanish Guide (ITEMS Guide). Part I: Cow Milk and Egg Oral Immunotherapy: Introduction, Methodology, Rationale, Current State, Indications, Contraindications, and Oral Immunotherapy Build-up Phase.research article28731411open access10.18176/jiaci.0177http://www.jiaci.org/revistas/10.18176_jiaci.0177_supplementaryappendix1.pdf