Triviño-Ibañez, Eva MariaJimenez-Rodriguez, Beatriz MariaRudolphi-Solero, TeodoroGarcia-Rivero, Encarnación YolandaRodriguez-Fernandez, AntonioLlamas-Elvira, Jose ManuelGomez-Rio, ManuelMorales-Garcia, Concepcion2023-05-032023-05-032022-03-24Triviño-Ibáñez EM, Jiménez-Rodríguez BM, Rudolphi-Solero T, García-Rivero EY, Rodríguez-Fernández A, et al. [18F]FDG PET/CT in Short-Term Complications of COVID-19: Metabolic Markers of Persistent Inflammation and Impaired Respiratory Function. Diagnostics (Basel). 2022 Mar 29;12(4):835.2075-4418http://hdl.handle.net/10668/20960SARS-CoV-2 virus infects organs other than the lung, such as mediastinal lymph nodes, spleen, and liver, but, to date, metabolic imaging studies obtained in short-term follow-ups of patients hospitalized with severe COVID-19 infection are rare. Our objective was to evaluate the usefulness of [18F]FDG-PET/CT in the short-term follow-up of patients admitted for COVID-19 pneumonia and to explore the association of the findings with clinical prognostic markers. The prospective study included 20 patients with COVID-19 pneumonia (November 2020-March 2021). Clinical and laboratory test findings were gathered at admission, 48-72 h post-admission, and 2-3 months post-discharge, when [18F]FDG-PET/CT and respiratory function tests were performed. Lung volumes, spirometry, lung diffusion capacity for carbon monoxide (DLCO), and respiratory muscle strength were measured. Volumetric [18F]FDG-PET/CT results were correlated with laboratory and respiratory parameters. Eleven [18F]FDG-PET/CT (55%) were positive, with hypermetabolic mediastinal lymphadenopathy in 90.9%. Mediastinal lesion's SUVpeak was correlated with white cells' count. Eleven (55%) patients had impaired respiratory function, including reduced DLCO (35%). SUVpeak was correlated with %predicted-DLCO. TLG was negatively correlated with %predicted-DLCO and TLC. In the short-term follow-up of patients hospitalized for COVID-19 pneumonia, [18F]FDG-PET/CT findings revealed significant detectable inflammation in lungs and mediastinal lymph nodes that correlated with pulmonary function impairment in more than half of the patients.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/COVID-19SARS-CoV-2[18F]FDG-PET/CTcomplicationsinflammatoryrespiratory function testHumansFluorodeoxyglucose F18Prospective StudiesCarbon MonoxidePrognosisSpleenPositron Emission Tomography Computed TomographyPatient DischargeAftercareFollow-Up StudiesLungLiverInflammationLymph NodesLymphadenopathySpirometryLung Volume Measurementsresearch article35453883open accessAlta del pacienteBazoCuidados posterioresEspirometríaEstudios prospectivosEstudios de seguimientoFluorodesoxiglucosa F18Ganglios linfáticosHígadoInflamaciónLinfadenopatíaMediciones del volumen pulmonarMonóxido de carbonoTomografía computarizada por tomografía de emisión de positronesPulmón10.3390/diagnostics12040835PMC9025979https://www.mdpi.com/2075-4418/12/4/835/pdf?version=1648530249https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025979/pdf