Morales, Javier SValenzuela, Pedro LCastillo-Garcia, AdriánButragueño, JavierJimenez-Pavon, DavidCarrera-Bastos, PedroLucia, Alejandro2023-05-032023-05-032021-12-19Morales JS, Valenzuela PL, Castillo-García A, Butragueño J, Jiménez-Pavón D, Carrera-Bastos P, et al. The Exposome and Immune Health in Times of the COVID-19 Pandemic. Nutrients. 2021 Dec 22;14(1):24http://hdl.handle.net/10668/21447Growing evidence supports the importance of lifestyle and environmental exposures-collectively referred to as the 'exposome'-for ensuring immune health. In this narrative review, we summarize and discuss the effects of the different exposome components (physical activity, body weight management, diet, sun exposure, stress, sleep and circadian rhythms, pollution, smoking, and gut microbiome) on immune function and inflammation, particularly in the context of the current coronavirus disease 2019 (COVID-19) pandemic. We highlight the potential role of 'exposome improvements' in the prevention-or amelioration, once established-of this disease as well as their effect on the response to vaccination. In light of the existing evidence, the promotion of a healthy exposome should be a cornerstone in the prevention and management of the COVID-19 pandemic and other eventual pandemics.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/COVID-19Environmental exposureHealthy lifestyleInfectious diseasesVaccinesBody weight maintenanceCOVID-19Circadian rhythmDietEnvironmental pollutantsExerciseExposomeGastrointestinal microbiomeHumansPandemicsSARS-CoV-2SleepSmokingStress, psychologicalSunlightresearch article35010900open accessContaminantes ambientalesDietaEjercicio físicoEstrés psicológicoExposomaFumarLuz solarMantenimiento del peso corporal10.3390/nu140100242072-6643PMC8746533https://www.mdpi.com/2072-6643/14/1/24/pdf?version=1640224122https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746533/pdf