Mena, AdrianaMedina, Daniel AGarcia-Martinez, JoseBegley, VictoriaSingh, AbhyudaiChavez, SebastianMuñoz-Centeno, Mari CPerez-Ortin, Jose E2023-01-252023-01-252017-10-23Mena A, Medina DA, García-Martínez J, Begley V, Singh A, Chávez S, et al. Asymmetric cell division requires specific mechanisms for adjusting global transcription. Nucleic Acids Res. 2017 Dec 1;45(21):12401-12412.http://hdl.handle.net/10668/11729Most cells divide symmetrically into two approximately identical cells. There are many examples, however, of asymmetric cell division that can generate sibling cell size differences. Whereas physical asymmetric division mechanisms and cell fate consequences have been investigated, the specific problem caused by asymmetric division at the transcription level has not yet been addressed. In symmetrically dividing cells the nascent transcription rate increases in parallel to cell volume to compensate it by keeping the actual mRNA synthesis rate constant. This cannot apply to the yeast Saccharomyces cerevisiae, where this mechanism would provoke a never-ending increasing mRNA synthesis rate in smaller daughter cells. We show here that, contrarily to other eukaryotes with symmetric division, budding yeast keeps the nascent transcription rates of its RNA polymerases constant and increases mRNA stability. This control on RNA pol II-dependent transcription rate is obtained by controlling the cellular concentration of this enzyme.enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/Cell CycleDNA-Directed RNA PolymerasesRNA StabilitySaccharomyces cerevisiaeTranscription, GeneticCell DivisionCell SizeRNA Polymerase IRNA, MessengerSaccharomyces cerevisiae Proteinsresearch article29069448open accessCélulasARN MensajeroSaccharomyces cerevisiaeARN Polimerasas dirigidas por ADNEstabilidad del ARNEucariontesEnzimasDivisión celular asimétrica10.1093/nar/gkx9741362-4962PMC5716168https://academic.oup.com/nar/article-pdf/45/21/12401/22146542/gkx974.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716168/pdf