IL7RA rs6897932 Polymorphism is Associated with Better CD4+ T-Cell Recovery in HIV Infected Patients Starting Combination Antiretroviral Therapy.

Resino, SalvadorNavarrete-Muñoz, María ABlanco, JuliàPacheco, Yolanda MCastro, IvánBerenguer, JuanSantos, JesúsVera-Méndez, Francisco JGórgolas, MiguelJiménez-Sousa, M A ÁngelesBenito, José MRallón, NormaCoRIS and the HIV Biobank integrated in the Spanish AIDS Research Network Project RIS/EPICLIN 10_20152023-01-252023-01-252019-06-16http://hdl.handle.net/10668/14132Interleukin-7 receptor subunit alpha (IL7RA) rs6897932 polymorphism is related to CD4+ recovery after combination antiretroviral therapy (cART), but no studies so far have analyzed its potential impact in patients with very low CD4+ T-cells count. We aimed to analyze the association between IL7RA rs6897932 polymorphism and CD4+ T-cells count restoration in HIV-infected patients starting combination antiretroviral therapy (cART) with CD4+ T-cells count 20% and was in Hardy-Weinberg equilibrium (p = 0.550). Of 411 patients, 256 carried the CC genotype, while 155 had the CT/TT genotype. The CT/TT genotype was associated with a higher slope of CD4+ T-cells recovery (arithmetic mean ratio; AMR = 1.16; p = 0.016), higher CD4+ T-cells increase (AMR = 1.19; p = 0.004), and higher CD4+ T-cells count at the end of follow-up (AMR = 1.13; p = 0.006). Besides, rs6897932 CT/TT was related to a higher odds of having a value of CD4+ T-cells at the end of follow-up ≥500 CD4+ cells/mm3 (OR = 2.44; p = 0.006). After multiple testing correction (Benjamini-Hochberg), only the increase of ≥ 400 CD4+ cells/mm3 lost statistical significance (p = 0.052). IL7RA rs6897932 CT/TT genotype was related to a better CD4+ T-cells recovery and it could be used to improve the management of HIV-infected patients starting cART with CD4+ T-cells countenAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/CD4HIVIL7RASNPscARTimmune reconstitutionAdultAnti-Retroviral AgentsCD4 Lymphocyte CountDrug InteractionsFemaleGenotypeHIV InfectionsHumansMaleMiddle AgedPolymorphism, Single NucleotideReceptors, Interleukin-7IL7RA rs6897932 Polymorphism is Associated with Better CD4+ T-Cell Recovery in HIV Infected Patients Starting Combination Antiretroviral Therapy.research article31208153open access10.3390/biom90602332218-273XPMC6627042https://www.mdpi.com/2218-273X/9/6/233/pdf?version=1561512700https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627042/pdf