Fernandez-Zamora, Maria DoloresGordillo-Brenes, AntonioBanderas-Bravo, EstherArboleda-Sánchez, José AndrésHinojosa-Pérez, RafaelAguilar-Alonso, EduardoHerruzo-Aviles, ÁngelCuriel-Balsera, EmilioSánchez-Rodríguez, ÁngelRivera-Fernández, RicardoARIAM Andalucía Group2023-01-252023-01-252018-01-30http://hdl.handle.net/10668/12064Mortality among the small percentage of cardiac surgery patients receiving prolonged mechanical ventilation is high, but this issue appears to be inadequately addressed in guidelines. This study is a retrospective analysis of prospective, multi-center, and observational study in Spain including all adults undergoing cardiac surgery in 3 Andalusian hospitals between June 2008 and December 2012. The study included 3,588 adults with mean ± SD age of 63.5 ± 12.8 y and with median (interquartile range) EuroSCORE of 5 (3-7) points. Prolonged mechanical ventilation (> 24 h) was required by 415 subjects (11.6%), with ICU mortality of 44.3% (184 subjects), and was not required by 3,173 subjects (88.4%), with ICU mortality of 3.1% (99 subjects, P 24 h) was required by 415 subjects (11.6%), with ICU mortality of 44.3% (184 subjects), and was not required by 3,173 subjects (88.4%), with ICU mortality of 3.1% (99 subjects, P 10. In the multivariable analysis, ICU mortality was associated with illness severity, duration of bypass surgery, surgery type, and prolonged mechanical ventilation (odds ratio 15.19, 95% CI 11.56-22.09). The main cause of death was multiple organ failure and sepsis in subjects who required prolonged mechanical ventilation (50.3%) and cardiogenic shock in those who did not (59.2%). Prolonged postoperative mechanical ventilation was required by 10-20% of cardiac surgery subjects, who constitute a specific group that represents most of the postoperative mortality, which is associated with multiple organ failure and sepsis.encardiac surgerymechanical ventilationmortalityseverityAgedCardiac Surgical ProceduresCause of DeathFemaleHumansIntensive Care UnitsMaleMiddle AgedMultiple Organ FailureOperative TimePostoperative ComplicationsProspective StudiesRespiration, ArtificialRisk FactorsSepsisSpainTime Factorsresearch article29382792open access10.4187/respcare.049151943-3654http://rc.rcjournal.com/content/respcare/63/5/550.full.pdf