Martino, AlessandroSainz, JuanBuda, GabrieleJamroziak, KrzysztofReis, Rui ManuelGarcía-Sanz, RamónJurado, ManuelRíos, RafaelSzemraj-Rogucka, ZofiaMarques, HerlanderLesueur, FabienneMoreno, VictorOrciuolo, EnricoGemignani, FedericaLandi, StefanoRossi, Anna MariaDumontet, CharlesPetrini, MarioCampa, DanieleCanzian, Federico2013-11-152013-11-152012-03Martino A, Sainz J, Buda G, Jamroziak K, Reis RM, García-Sanz R, et al. Genetics and molecular epidemiology of multiple myeloma: the rationale for the IMMEnSE consortium (review). Int. J. Oncol. 2012; 40(3):625-381019-6439http://hdl.handle.net/10668/1379Journal Article; Research Support, Non-U.S. Gov't; Review;There is strong evidence suggesting the presence of a genetic component in the aetiology of multiple myeloma (MM). However no genetic risk factors have been unequivocally established so far. To further our understanding of the genetic determinants of MM risk, a promising strategy is to collect a large set of patients in a consortium, as successfully done for other cancers. In this article, we review the main findings in the genetic susceptibility and pharmacogenetics of MM and present the strategy of the IMMEnSE (International Multiple Myeloma rESEarch) consortium in contributing to determine the role of genetic variation in pharmacogenetics and in MM risk.enIMMEnSE consortium,Multiple myelomaSNPsGenetic susceptibilityHharmacogeneticsHumanosVariación GenéticaFarmacogenéticaFactores de Riesg0Mieloma MúltipleEpidemiología MolecularMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic VariationMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Molecular EpidemiologyMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Plasma Cell::Multiple MyelomaMedical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::PharmacogeneticsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk FactorsMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to Diseaseresearch article22159523open access10.3892/ijo.2011.12841791-2423