Muñoz, Gerardde Gracia, JavierGiron, RosaOlveira, CasildaAlvarez, AntonioBuxó, MariaBirring, Surinder S.Vendrell, Montserrat2023-01-112023-01-112021-11-03Muñoz G, de Gracia J, Giron R, Olveira C, Alvarez A, Buxó M, et al. Validation of a Spanish version of the Leicester Cough Questionnaire in cystic fibrosis. Chron Respir Dis. 2021 Jan-Dec;18:147997312110369031479-9723http://hdl.handle.net/10668/4561Cough is a main symptom in cystic fibrosis (CF). We aim to validate a Spanish version of the Leicester Cough Questionnaire (LCQ-Sp) to measure the impact of cough in CF bronchiectasis. A prospective longitudinal multicentre study was performed. Internal consistency and score changes over a 15-day period in stable state were assessed to analyse reliability. Concurrent validity was analysed by correlation with Saint George's Respiratory Questionnaire (SGRQ) and convergent validity by assessing the association with clinical variables. Changes in scores between stable state and the first exacerbation were assessed to analyse responsiveness. 132 patients (29.73 ± 10.52 years) were enrolled in four hospitals. Internal consistency was high for the total score and good for the three domains (Cronbach's α 0.81-0.93). The test-retest reliability showed an intraclass correlation coefficient of 0.86 for the total score. The correlation between LCQ-Sp and SGRQ scores was -0.74. The LCQ-Sp score negatively correlated with sputum volume, and the mean score decreased at the beginning of exacerbations (16.04±3.81 vs 13.91±4.29) with a large effect size. The LCQ-Sp is a reliable, repeatable and responsive instrument to assess the impact of cough in CF bronchiectasis and is responsive to change in the event of exacerbations.enAtribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/Cystic fibrosisCoughQuality of lifeBronchiectasisSymptomsRespiratory diseaseSputumFibrosis quísticaTosCalidad de vidaBronquiectasiaEnfermedades respiratoriasEsputoMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective StudiesMedical Subject Headings::Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Quality of LifeMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Reproducibility of ResultsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::QuestionnairesMedical Subject Headings::Diseases::Respiratory Tract Diseases::Respiration Disorders::CoughMedical Subject Headings::Diseases::Digestive System Diseases::Pancreatic Diseases::Cystic FibrosisMedical Subject Headings::Anatomy::Fluids and Secretions::Bodily Secretions::SputumMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptomsresearch article34730449open access10.1177/147997312110369031479-9731PMC8743974