López-Moreno, AnaAguilera, Margarita2022-09-272022-09-272021-04-02López-Moreno A, Aguilera M. Vaginal Probiotics for Reproductive Health and Related Dysbiosis: Systematic Review and Meta-Analysis. J Clin Med. 2021 Apr 2;10(7):1461http://hdl.handle.net/10668/4155The use of probiotics in reproductive-related dysbiosis is an area of continuous progress due to the growing interest from clinicians and patients suffering from recurrent reproductive microbiota disorders. An imbalance in the natural colonization sites related to reproductive health-vaginal, cervicovaginal, endometrial, and pregnancy-related altered microbiota-could play a decisive role in reproductive outcomes. Oral and vaginal administrations are in continuous discussion regarding the clinical effects pursued, but the oral route is used and studied more often despite the need for further transference to the colonization site. The aim of the present review was to retrieve the standardized protocols of vaginal probiotics commonly used for investigating their microbiota modulation capacities. Most of the studies selected focused on treating bacterial vaginosis (BV) as the most common dysbiosis; a few studies focused on vulvovaginal candidiasis (VVC) and on pretreatment during in vitro fertilization (IVF). Vaginal probiotic doses administered were similar to oral probiotics protocols, ranging from ≥107 CFU/day to 2.5 × 1010 CFU/day, but were highly variable regarding the treatment duration timing. Moderate vaginal microbiota modulation was achieved; the relative abundance of abnormal microbiota decreased and Lactobacillus species increased.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Vaginal probioticsReproductive dysbiosisBacterial vaginosisVVCIVFProbióticosVaginaDisbiosisSalud reproductivaVaginitis bacterianaCandidiasis vulvovaginalFecundación in vitroMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::PregnancyMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Vaginosis, BacterialMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Mycoses::Candidiasis::Candidiasis, VulvovaginalMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::DysbiosisMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Administration Routes::Administration, Topical::Administration, IntravaginalMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Administration Routes::Administration, Topical::Administration, IntravaginalMedical Subject Headings::Health Care::Population Characteristics::Health::Reproductive HealthMedical Subject Headings::Organisms::Bacteria::Gram-Positive Bacteria::Lactobacillales::Lactobacillaceae::LactobacillusMedical Subject Headings::Technology and Food and Beverages::Food and Beverages::Food::Dietary Supplements::ProbioticsMedical Subject Headings::Phenomena and Processes::Microbiological Phenomena::MicrobiotaMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Reproductive Techniques::Reproductive Techniques, Assisted::Fertilization in VitroMedical Subject Headings::Information Science::Information Science::Communications Media::Publications::Review Literature as Topicreview article33918150Acceso abierto10.3390/jcm100714612077-0383PMC8037567