Pérez-Belmonte, Luis MMoreno-Santos, InmaculadaCabrera-Bueno, FernandoSánchez-Espín, GemmaCastellano, DanielSuch, MiguelCrespo-Leiro, María GCarrasco-Chinchilla, FernandoAlonso-Pulpón, LuisLópez-Garrido, MiguelRuiz-Salas, AmalioBecerra-Muñoz, Víctor MGómez-Doblas, Juan Jde Teresa-Galván, EduardoJiménez-Navarro, Manuel2023-01-252023-01-252017-02-23http://hdl.handle.net/10668/11037Objectives: Sterol regulatory element-binding proteins (SREBP) genes are crucial in lipid biosynthesis and cardiovascular homeostasis. Their expression in epicardial adipose tissue (EAT) and their influence in the development of coronary artery disease (CAD) and type-2 diabetes mellitus remain to be determined. The aim of our study was to evaluate the expression of SREBP genes in EAT in patients with CAD according to diabetes status and its association with clinical and biochemical data. Methods: SREBP-1 and SREBP-2 mRNA expression levels were measured in EAT from 49 patients with CAD (26 with diabetes) and 23 controls without CAD or diabetes. Results: Both SREBPs mRNA expression were significantly higher in patients with CAD and diabetes (penAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/Sterol regulatory element-binding proteins (SREBP)coronary artery diseaseepicardial adipose tissuetype-2 diabetes mellitus.Adipose TissueAgedCoronary Artery DiseaseDiabetes Mellitus, Type 2FemaleHumansLipid MetabolismMaleMiddle AgedPericardiumRisk FactorsSterol Regulatory Element Binding Protein 1Sterol Regulatory Element Binding Protein 2Sterolsresearch article28367087open access10.7150/ijms.178211449-1907PMC5370289http://www.medsci.org/v14p0268.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370289/pdf