Santa-Cruz, Diana C.Caparros-Gonzalez, Rafael A.Romero-Gonzalez, BorjaPeralta-Ramirez, Maria IsabelGonzalez-Perez, RaquelGarcía-Velasco, Juan Antonio2022-10-172022-10-172020-04-27Santa-Cruz DC, Caparros-Gonzalez RA, Romero-Gonzalez B, Peralta-Ramirez MI, Gonzalez-Perez R, García-Velasco JA. Hair Cortisol Concentrations as a Biomarker to Predict a Clinical Pregnancy Outcome after an IVF Cycle: A Pilot Feasibility Study. Int J Environ Res Public Health. 2020 Apr 27;17(9):30201661-7827http://hdl.handle.net/10668/4250Our objective was to examine the feasibility of hair cortisol concentrations (HCC) as a biomarker to predict clinical pregnancy outcomes and investigate its potential associations with perceived anxiety, resilience, and depressive symptoms. A total of 43 participants were assessed using HCC, the state trait anxiety inventory (STAI), resilience scale (RS), and the depression subscale of the symptom checklist 90-R (SCL-90-R). Participants were approached at their second consultation with the reproductive endocrinologist (T1), before scheduling their IVF cycle, and then 12 weeks after (T2), at their post-transfer visit with the study coordinators, before the human chorionic gonadotropin (HCG) pregnancy test. The logistic regression model revealed that HCC at T2 predicted 46% of a positive pregnancy test [R2 = 0.46, (ß = 0.11, p < 0.05)]. Pregnant women had higher levels of resilience at T2 (M = 149.29; SD = 17.56) when compared with non-pregnant women at T2 (M = 119.96; SD = 21.71). Significant differences were found between both groups in depression at T2 (t = 3.13, p = 0.01) and resilience at T2 (t = -4.89, p = 0.01). HCC might be a promising biomarker to calculate the probability of pregnancy in women using assisted reproductive technologies (ART).enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/InfertilityPregnancyCortisolStressHairVitro fertilizationDepressionHydrocortisoneInfertilidadEmbarazoEstrés fisiológicoCabelloFertilización in vitroDepresiónHidrocortisonaMedical Subject Headings::Persons::Persons::Age Groups::AdultMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Feasibility StudiesMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Reproductive Techniques::Reproductive Techniques, Assisted::Fertilization in VitroMedical Subject Headings::Anatomy::Integumentary System::HairMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::PregnancyMedical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy::Pregnancy OutcomeMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Stress, PsychologicalMedical Subject Headings::Chemicals and Drugs::Biological Factors::Biological MarkersMedical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Steroids::Pregnanes::Pregnenes::Pregnenediones::HydrocortisoneMedical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Pregnancy ComplicationsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Reproductive Techniques::Reproductive Techniques, AssistedMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::DepressionMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical::Models, Statistical::Logistic ModelsMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions::AnxietyMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Reproductive Techniques::Reproductive Techniques, Assisted::Fertilization in VitroMedical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Gonadotropins::Chorionic GonadotropinMedical Subject Headings::Health Care::Health Services Administration::Organization and Administration::Professional Practice::Referral and Consultationresearch article32349221Acceso abierto10.3390/ijerph170930201660-4601PMC7246651