Fenoll, AsunciónArdanuy, CarmenLiñares, JosefinaCercenado, EmiliaMarco, FrancescFleites, AnaRodríguez-Mayo, MaríaLópez-Hontangas, Jose-LuisPalop, BegoñaAller, Ana-IsabelBuendía, BuenaventuraMéndez, CristinaCifuentes, IsabelODIN Study Group2023-01-252023-01-252018-11-16http://hdl.handle.net/10668/13204Serotypes/genotypes causing invasive pneumococcal disease (IPD) in adults are determined by vaccination strategies. The aim of this study was to assess the epidemiology of IPD in adults (≥18 years) after PCV13 introduction for children: serotypes, clonal complexes, antibiotic non-susceptibility and clinical presentations. We performed a prospective, clinical surveillance of hospitalized culture-confirmed IPDs in adults in nine Spanish hospitals (August 2010-June 2015). A total of 1087 culture-confirmed IPD episodes were included, of which 772 (71.0%) had bacteremic pneumonia (401 complicated/371 uncomplicated pneumonia), 122 (11.2%) meningitis, 102 (9.4%) non-focal bacteremia, 34 (3.1%) peritonitis and 57 (5.3%) others. The most common serotypes were: 3 (12.7%), 19A (8.5%), 8 (7.7%), 7F (6.3%), 1 (4.2%), 6C (4.2%), 11A (4.2%), 22F (4.2%) and 14 (4.0%). Vaccine types (PCV13 + 6C) caused 49.8% of IPD episodes, with a significant decrease over the 5-year period, and significant decreases in serotypes 6C and 7F. The most common genotypes were: CC180 (8.4%), CC191 (6.0%), and CC53 (5.0%). Vaccine types caused 53.9% (414/768) pneumonia episodes and 58.9% (235/399) complicated pneumonia, 53.4% IPD in adultsenAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Clonal complexInvasive pneumococcal diseasePCV13SerotypeStreptococcus pneumoniaeAdultAgedBacteremiaEpidemiological MonitoringFemaleGenotypeHospitalizationHumansLicensureMaleMiddle AgedPneumococcal InfectionsPneumococcal VaccinesProspective StudiesSerogroupSerotypingSpainStreptococcus pneumoniaeYoung Adultresearch article30449634open access10.1016/j.vaccine.2018.10.0981873-2518http://diposit.ub.edu/dspace/bitstream/2445/156783/1/688891.pdf