Fragata, IsabelBustamante, AlejandroPenalba, AnnaFerreira, PatríciaNunes, Ana PaivaCanhão, PatríciaMontaner, Joan2023-01-252023-01-252019http://hdl.handle.net/10668/13451There is increasing evidence for the role of inflammation in clinical outcome after subarachnoid hemorrhage (SAH). Specifically, the TNF-alfa(α) pathway seems to be relevant after SAH. Although the TNF-α main receptor, TNF-R1 is associated with aneurysm growth and rupture, its relation to prognosis is unknown. We sought to compare TNF-R1 levels in peripheral venous blood and arterial blood closer to the ruptured aneurysm to study the association of TNF-R1 blood levels with poor prognosis (modified Rankin Scale  > 2 at discharge, 3 and 6 months) and complications (hydrocephalus or delayed cerebral ischemia/DCI) following SAH. We included consecutive SAH patients admitted in the first 72 h of symptoms. Blood samples were simultaneously collected from a peripheral vein and from the main parent artery of the aneurysm. Levels of TNF-R1 were measured using enzyme-linked immunosorbent assays. We analyzed 58 patients. Arterial and venous levels of TNF-R1 were correlated (R = 0.706, p  Levels of venous TNF-R1 are associated with poor outcome in SAH. A specific association was found between levels of arterial TNF-R1 and hydrocephalus. These results are consistent with the role of TNF-α pathway in SAH and need to be validated in larger cohorts.enDelayed cerebral ischemiaHydrocephalusPrognosisSubarachnoid hemorrhageTNF-R1AdultAgedArteriesCohort StudiesFemaleHumansMaleMiddle AgedPredictive Value of TestsROC CurveReceptors, Tumor Necrosis Factor, Type ISubarachnoid HemorrhageTreatment OutcomeVeinsresearch article30673997open access10.1007/s12028-019-00669-91556-0961http://repositorio.chlc.min-saude.pt/bitstream/10400.17/3572/1/Neurocrit%20Care%202019%20107.pdf