Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count.

Ruiz-de-León, María JJiménez-Sousa, María AMoreno, SantiagoGarcía, MarcialGutiérrez-Rivas, MónicaLeón, AgatheMontero-Alonso, MartaGonzález-García, JuanResino, SalvadorRallón, NormaBenito, José MVallejo, AlejandroECRIS Network integrated in the Spanish AIDS Research Network2023-01-252023-01-252018-08-24http://hdl.handle.net/10668/12921Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137-0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = -0.649, p = 0.020), while no correlation between soluble biomarkers or cellular immune activation was found.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Elite controllersExosomesHIV-1Immune activationSoluble biomarkersmiRNAsAdultBiomarkersCD4 Lymphocyte CountCD4-Positive T-LymphocytesChemokine CCL2Cross-Sectional StudiesExosomesFemaleHIV InfectionsHIV-1HumansMaleMicroRNAsMiddle AgedPlasmaLower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count.research article30193823open access10.1016/j.jmii.2018.07.0071995-9133https://doi.org/10.1016/j.jmii.2018.07.007