Herrmann, FlorianNieto-Ruiz, AnaSepulveda-Valbuena, NataliaMiranda, M. TeresaDieguez, EstefaniaJimenez, JesusDe-Castellar, RoserGarcia-Ricobaraza, MariaGarcia-Santos, Jose AntonioBermudez, Mercedes G.Campoy, Cristina2023-02-122023-02-122021-05-02Florian Herrmann, Ana Nieto-Ruiz, Natalia Sepúlveda-Valbuena, M. Teresa Miranda, Estefanía Diéguez, Jesús Jiménez, et al. Infant formula enriched with milk fat globule membrane, long-chain polyunsaturated fatty acids, synbiotics, gangliosides, nucleotides and sialic acid reduces infections during the first 18 months of life: The COGNIS study, Journal of Functional Foods, Volume 83, 2021, 104529,1756-4646http://hdl.handle.net/10668/18821Functional nutrients like synbiotics or milk-fat globule membrane (MFGM) affect positively host immunity, modifying intestinal microbioma and reducing early childhood infections. We compared effects of an experimental enriched-infant formula with long chain polyunsaturated fatty acids, MFGM, synbiotics, sialic acid, nucleotides and gangliosides to a standard infant formula and breastfeeding regarding infections incidence and evolution in infants until 18 months of age. 170 healthy infants were enrolled in a RCT to receive either a bioactive functional nutrients enriched infant formula (EF, n = 85) or a standard formula (SF, n = 85). 50 breastfed (BF) infants were also enrolled. At age 12 months, EF group compared to SF and BF groups showed a lower incidence of infectious episodes. Moreover, they also presented less incidence of respiratory tract infections and gastrointestinal infections than SF infants, reducing risk by 30.2% and 32.5%, respectively. Infants fed with an EF seem to have reduced incidence of certain infections at 12 months of age.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Early nutritionInfectionMilk fat globule membraneRespiratory-tract infectionsDouble-blindPrebiotic oligosaccharidesProbioticsCareRiskEfficacyDiarrheaSafetyPreventionChild, PreschoolInfantBreast FeedingInfant FormulaGangliosidesIncidenceMilkSynbioticsCommunicable DiseasesRespiratory Tract InfectionsSialic Acidsresearch articleopen accessEnfermedades transmisiblesFórmulas infantilesGangliósidosIncidenciaInfecciones del sistema respiratorioLactancia maternaLactanteLechePreescolarSimbióticosÁcidos siálicos10.1016/j.jff.2021.1045292214-9414https://doi.org/10.1016/j.jff.2021.104529687459400001