Luján-Sanchis, MPérez-Cuadrado-Robles, EGarcía-Lledó, JJuanmartiñena Fernández, JFElli, LJiménez-García, VAEgea-Valenzuela, JValle-Muñoz, JCarretero-Ribón, CFernández-Urién-Sainz, ILópez-Higueras, AAlonso-Lázaro, NSanjuan-Acosta, MSánchez-Ceballos, FRosa, BGonzález-Vázquez, SBranchi, FRuano-Díaz, IPrieto-De-Frías, CPons-Beltrán, VBorque-Barrera, PGonzález-Suárez, BXavier, SArgüelles-Arias, FHerrerías-Gutiérrez, JMPérez-Cuadrado-Martínez, ESempere-García-Argüelles, J2017-05-182017-05-182017-01-28Luján-Sanchis M, Pérez-Cuadrado-Robles E, García-Lledó J, Juanmartiñena Fernández JF, Elli L, Jiménez-García V A, Egea-Valenzuela J, et al. Role of capsule endoscopy in suspected celiac disease: A European multi-centre study. World Journal of Gastroenterology. 2017;23(4):703-7111007-9327http://hdl.handle.net/10668/2649AIM To analyze the diagnostic yield (DY), therapeutic impact (TI) and safety of capsule endoscopy (CE). METHODS This is a multi-centre, observational, analytical, retrospective study. A total of 163 patients with suspicion of celiac disease (CD) (mean age = 46.4 ± 17.3 years, 68.1% women) who underwent CE from 2003 to 2015 were included. Patients were divided into four groups: seronegative CD with atrophy (Group- ?, n = 19), seropositive CD without atrophy (Group- ?, n = 39), contraindication to gastroscopy (Group-?, n = 6), seronegative CD without atrophy, but with a compatible context (Group-?, n = 99). DY, TI and the safety of CE were analysed. RESULTS The overall DY was 54% and the final diagnosis was villous atrophy (n = 65, 39.9%), complicated CD (n = 12, 7.4%) and other enteropathies (n = 11, 6.8%; 8 Crohn's). DY for groups ? to ? was 73.7%, 69.2%, 50% and 44.4%, respectively. Atrophy was located in duodenum in 24 cases (36.9%), diffuse in 19 (29.2%), jejunal in 11 (16.9%), and patchy in 10 cases (15.4%). Factors associated with a greater DY were positive serology (68.3% vs 49.2%, P = 0.034) and older age (P = 0.008). On the other hand, neither sex nor clinical presentation, family background, positive histology or HLA status were associated with DY. CE results changed the therapeutic approach in 71.8% of the cases. Atrophy was associated with a greater TI (92.3% vs 45.3%, P < 0.001) and 81.9% of the patients responded to diet. There was one case of capsule retention (0.6%). Agreement between CE findings and subsequent histology was 100% for diagnosing normal/other conditions, 70% for suspected CD and 50% for complicated CD. CONCLUSION CE has a high DY in cases of suspicion of CD and it leads to changes in the clinical course of the disease. CE is safe procedure with a high degree of concordance with histology and it helps in the differential diagnosis of CD. © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.esAnti-transglutaminase antibodiesCapsule endoscopyCeliac diseaseGluten-free dietNon-celiac gluten sensitivityAtrofiaEndoscopía capsularEnfermedad celíacaEnfermedad de CrohnMedical Subject Headings::Named Groups::Persons::Age Groups::AdultMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathological Conditions, Anatomical::AtrophyMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Surgical::Endoscopy::Endoscopy, Digestive System::Endoscopy, Gastrointestinal::Capsule EndoscopyMedical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseases::Intestinal Diseases::Malabsorption Syndromes::Celiac DiseaseMedical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Inflammatory Bowel Diseases::Crohn DiseaseMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnosis, DifferentialMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::DietMedical Subject Headings::Anatomy::Digestive System::Gastrointestinal Tract::Intestines::Intestine, Small::DuodenumMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Digestive System::Endoscopy, Digestive System::Endoscopy, Gastrointestinal::GastroscopyMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseases::Intestinal DiseasesMedical Subject Headings::Anatomy::Digestive System::Gastrointestinal Tract::Intestines::Intestine, Small::JejunumMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle AgedMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studiesresearch article28216978open access10.3748/wjg.v23.i4.7032219-2840