Garcia-Revilla, JuanDeierborg, TomasVenero, Jose LuisBoza-Serrano, Antonio2021-02-122021-02-122020-08-18Garcia-Revilla J, Deierborg T, Venero JL, Boza-Serrano A. Hyperinflammation and Fibrosis in Severe COVID-19 Patients: Galectin-3, a Target Molecule to Consider. Front Immunol. 2020 Aug 18;11:2069.http://hdl.handle.net/10668/3245COVID-19 disease have become so far the most important sanitary crisis in the XXI century. In light of the events, any clinical resource should be considered to alleviate this crisis. Severe COVID-19 cases present a so-called cytokine storm as the most life-threatening symptom accompanied by lung fibrosis. Galectin-3 has been widely described as regulator of both processes. Hereby, we present compelling evidences on the potential role of galectin-3 in COVID-19 in the regulation of the inflammatory response, fibrosis and infection progression. Moreover, we provide a strong rationale of the utility of measuring plasma galectin-3 as a prognosis biomarker for COVID-19 patients and propose that inhibition of galectin-3 represents a feasible and promising new therapeutical approach.enCOVID-19Cytokine stormFibrosisGalectin-3BiomarkerInflammationInfecciones por coronavirusCitocinasGalectina 3Biomarcadores ambientalesInflamaciónMedical Subject Headings::Diseases::Respiratory Tract Diseases::Lung Diseases::Pulmonary FibrosisMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::CytokinesMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Lectins::Galectins::Galectin 3Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers::Biomarkers, PharmacologicalMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::InflammationMedical Subject Headings::Diseases::Respiratory Tract Diseases::Lung Diseases::PneumoniaMedical Subject Headings::Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infectionsresearch article32973815Acceso abiertohttps://doi.org/10.3389/fimmu.2020.020691664-3224PMC7461806