Lassale, CamilleGunter, Marc JRomaguera, DoraPeelen, Linda MVan der Schouw, Yvonne TBeulens, Joline W JFreisling, HeinzMuller, David CFerrari, PietroHuybrechts, IngeFagherazzi, GuyBoutron-Ruault, Marie-ChristineAffret, AurélieOvervad, KimDahm, Christina COlsen, AnjaRoswall, NinaTsilidis, Konstantinos KKatzke, Verena AKühn, TilmanBuijsse, BrianQuirós, José-RamónSánchez-Cantalejo, EmilioEtxezarreta, NereaHuerta, José MaríaBarricarte, AurelioBonet, CatalinaKhaw, Kay-TeeKey, Timothy JTrichopoulou, AntoniaBamia, ChristinaLagiou, PagonaPalli, DomenicoAgnoli, ClaudiaTumino, RosarioFasanelli, FrancescaPanico, SalvatoreBueno-de-Mesquita, H BasBoer, Jolanda M ASonestedt, EmilyNilsson, Lena MariaRenström, FridaWeiderpass, ElisabeteSkeie, GuriLund, EilivMoons, Karel G MRiboli, ElioTzoulaki, Ioanna2016-08-312016-08-312016-07-13Lassale C, Gunter MJ, Romaguera D, Peelen LM, Van der Schouw YT, Beulens JW, et al. Diet Quality Scores and Prediction of All-Cause, Cardiovascular and Cancer Mortality in a Pan-European Cohort Study. PLoS ONE 2016; 11(7):e0159025http://hdl.handle.net/10668/2384Journal Article;Scores of overall diet quality have received increasing attention in relation to disease aetiology; however, their value in risk prediction has been little examined. The objective was to assess and compare the association and predictive performance of 10 diet quality scores on 10-year risk of all-cause, CVD and cancer mortality in 451,256 healthy participants to the European Prospective Investigation into Cancer and Nutrition, followed-up for a median of 12.8y. All dietary scores studied showed significant inverse associations with all outcomes. The range of HRs (95% CI) in the top vs. lowest quartile of dietary scores in a composite model including non-invasive factors (age, sex, smoking, body mass index, education, physical activity and study centre) was 0.75 (0.72-0.79) to 0.88 (0.84-0.92) for all-cause, 0.76 (0.69-0.83) to 0.84 (0.76-0.92) for CVD and 0.78 (0.73-0.83) to 0.91 (0.85-0.97) for cancer mortality. Models with dietary scores alone showed low discrimination, but composite models also including age, sex and other non-invasive factors showed good discrimination and calibration, which varied little between different diet scores examined. Mean C-statistic of full models was 0.73, 0.80 and 0.71 for all-cause, CVD and cancer mortality. Dietary scores have poor predictive performance for 10-year mortality risk when used in isolation but display good predictive ability in combination with other non-invasive common risk factors.enSistema cardiovascularEstudios de cohortesDietaHábitos alimenticiosNeoplasiasEstado NutricionalEstudios ProspectivosFactores de RiesgoHábito de FumarÍndice de masa corporalActividad motoraMedical Subject Headings::Anatomy::Cardiovascular SystemMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort StudiesMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::DietMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Feeding Behavior::Food HabitsMedical Subject Headings::Diseases::NeoplasmsMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Nutritional StatusMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective StudiesMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk FactorsMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Habits::SmokingMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Mass IndexMedical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Motor Activityresearch article27409582open access10.1371/journal.pone.01590251932-6203PMC4943719