Araujo-Castro, MartaGarcía Centero, RogelioLópez-García, María-CarmenÁlvarez Escolá, CristinaCalatayud Gutiérrez, MaríaBlanco Carrera, ConcepciónDe Miguel Novoa, PazValdés Gallego, NuriaHanzu, Felicia AGracia Gimeno, PaolaFernández-Ladreda, Mariana ToméPercovich Hualpa, Juan CarlosMora Porta, MireiaLorca Álvaro, JavierPian, HéctorCaracuel, Ignacio RuzSanjuanbenito Dehesa, AlfonsoGómez Dos Santos, VictoriaSerrano Romero, AnaOliveira, Cristina Lamas2023-02-092023-02-092021-08-09http://hdl.handle.net/10668/18353To identify presurgical and surgical risk factors for postsurgical complications in the pheochromocytoma surgery. A retrospective study of pheochromocytomas submitted to surgery in ten Spanish hospitals between 2011 and 2021. Postoperative complications were classified according to Clavien-Dindo scale. One hundred and sixty-two surgeries (159 patients) were included. Preoperative antihypertensive blockade was performed in 95.1% of the patients, being doxazosin in monotherapy (43.8%) the most frequent regimen. Patients pre-treated with doxazosin required intraoperative hypotensive treatment more frequently (49.4% vs 25.0%, P = 0.003) than patients treated with phenoxybenzamine, but no differences in the rate of intraoperative and postsurgical complications were observed. However, patients treated with phenoxybenzamine had a longer hospital stay (12.2 ± 11.16 vs 6.2 ± 6.82, P  Preoperative medical treatment and postsurgical monitoring of pheochromocytoma should be especially careful in patients with diabetes, cerebrovascular disease, higher levels of plasma glucose and urine free metanephrine and norepinephrine, and with pheochromocytomas >5 cm, due to the higher risk of postsurgical complications.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Clavien-Dindo classificationPheochromocytomaPostsurgical complicationsPresurgical managementProlonged hypotensionUrine free metanephrinesAdrenal Gland NeoplasmsHumansPhenoxybenzaminePheochromocytomaRetrospective StudiesTreatment Outcomeresearch article34373995open access10.1007/s12020-021-02843-61559-0100https://www.researchsquare.com/article/rs-683836/latest.pdf