Fernandez-Garcia, LauraFernandez-Cuenca, FelipeBlasco, LuciaLopez-Rojas, RafaelAmbroa, AntonLopez, MariaPascual, AlvaroBou, GermanTomas, Maria2023-01-252023-01-252018-04-26Fernández-García L, Fernandez-Cuenca F, Blasco L, López-Rojas R, Ambroa A, Lopez M, et al. Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e00250-18.http://hdl.handle.net/10668/12158The molecular mechanisms of tolerance and persistence associated with several compounds in Acinetobacter baumannii clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imipenem in an A. baumannii strain belonging to clinical clone ST-2 (OXA-24 β-lactamase and AbkAB toxin-antitoxin [TA] system carried in a plasmid). Interestingly, the strain A. baumannii ATCC 17978 (AbkAB TA system from plasmid) showed persistence in the presence of imipenem and chlorhexidine.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Acinetobacterchlorhexidineimipenempersistencetolerancetoxin-antitoxinAcinetobacter InfectionsAcinetobacter baumanniiAnti-Bacterial AgentsChlorhexidineDrug Resistance, Multiple, BacterialDrug ToleranceHumansImipenemMicrobial Sensitivity TestsPlasmidsToxin-Antitoxin Systemsbeta-Lactamasesresearch article29463538open accessImipenemPlásmidosClorhexidinaAcinetobacter baumanniiPertenenciaAntitoxinas10.1128/AAC.00250-181098-6596PMC5923160https://doi.org/10.1128/aac.00250-18https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923160/pdf