Santos García, Diegode Deus Fonticoba, TeresaCores Bartolomé, CarlosNaya Ríos, LucíaGarcía Roca, LucíaMartínez Miró, CristinaCanfield, HectorJesús, SilviaAguilar, MiquelPastor, PauCosgaya, MarinaGarcía Caldentey, JuanCaballol, NuriaLegarda, InésHernández Vara, JorgeCabo, IriaLópez Manzanares, LydiaGonzález Aramburu, IsabelÁvila Rivera, María AGómez Mayordomo, VíctorNogueira, VíctorPuente, VíctorDotor, JulioBorrué, CarmenSolano Vila, BertaÁlvarez Sauco, MaríaVela, LydiaEscalante, SoniaCubo, EstherCarrillo Padilla, FranciscoMartínez Castrillo, Juan CSánchez Alonso, PilarAlonso Losada, Maria GLópez Ariztegui, NuriaGastón, ItziarKulisevsky, JaimeBlázquez Estrada, MartaSeijo, ManuelRúiz Martínez, JavierValero, CaridadKurtis, Mónicade Fábregues, OriolGonzález Ardura, JessicaAlonso Redondo, RubenOrdás, CarlosLópez Díaz, Luis MMcAfee, DarrianMartinez-Martin, PabloMir, PabloCoppadis Study Group,2025-01-072025-01-072021-09-292075-4418https://hdl.handle.net/10668/27951The aim of this study was to compare the progression of independence in activities of daily living (ADL) in Parkinson's disease (PD) patients versus a control group, as well as to identify predictors of disability progression and functional dependency (FD). PD patients and control subjects, who were recruited from 35 centers of Spain from the COPPADIS cohort between January 2016 and November 2017 (V0), were included. Patients and subjects were then evaluated again at the 2-year follow-up (V2). Disability was assessed with the Schwab & England Activities of Daily Living Scale (S&E-ADLS) at V0 and V2. FD was defined as an S&E-ADLS score less than 80%. In the PD group, a significant decrease in the S&E-ADLS score from V0 to V2 (N = 507; from 88.58 ± 10.19 to 84.26 ± 13.38; p In conclusion, autonomy for ADL worsens in PD patients compared to controls. Cognitive impairment, gait problems, fatigue, depressive symptoms, more advanced disease, and a non-tremor phenotype are independent predictors of FD in the short-term.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Parkinson’s diseaseactivities of daily livingdependencydisabilitygaitresearch article34679503open access10.3390/diagnostics11101801PMC8534700https://www.mdpi.com/2075-4418/11/10/1801/pdf?version=1632971933https://pmc.ncbi.nlm.nih.gov/articles/PMC8534700/pdf