Josa-Laorden, ClaudiaCrestelo-Vieitez, AnxelaGarcía Andreu, María Del MarRubio-Rivas, ManuelSánchez, MarcosToledo Samaniego, NeeraArnalich Fernández, FranciscoIguaran Bermudez, RosarioFonseca Aizpuru, Eva MaVargas Núñez, Juan AntonioPesqueira Fontan, Paula MariaSerrano Ballesteros, JorgeFreire Castro, Santiago JesúsPestaña Fernández, MelaniViana García, AlbaNuñez Rodriguez, VictoriaGiner-Galvañ, VicenteCarrasco Sánchez, Francisco JavierHernández Milián, AlmudenaCobos-Siles, MartaNapal Lecumberri, Jose JavierHerrero García, VirginiaPascual Pérez, Maria de Los ReyesMillán Núñez-Cortés, JesúsCasas Rojo, José ManuelOn Behalf Of The Semi-Covid-Network,2023-02-092023-02-092021-02-252077-0383http://hdl.handle.net/10668/17283There is some evidence that male gender could have a negative impact on the prognosis and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The aim of the present study was to compare the characteristics of coronavirus disease 2019 (COVID-19) between hospitalized men and women with confirmed SARS-CoV-2 infection. This multicenter, retrospective, observational study is based on the SEMI-COVID-19 Registry. We analyzed the differences between men and women for a wide variety of demographic, clinical, and treatment variables, and the sex distribution of the reported COVID-19 deaths, as well as intensive care unit (ICU) admission by age subgroups. This work analyzed 12,063 patients (56.8% men). The women in our study were older than the men, on average (67.9 vs. 65.7 years; penAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/COVID-19SARS-CoV-2Spaincoronavirusgender differencesresearch article33668766open access10.3390/jcm10050899PMC7956359https://www.mdpi.com/2077-0383/10/5/899/pdf?version=1614937117https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956359/pdf