Molina, NoemiGonzález, AnaMonopoli, DonatoMentado, BelindaBecerra, JoséSantos-Ruiz, LeonorVida, YolandaPerez-Inestrosa, Ezequiel2022-04-062022-04-062020-04-01Molina N, González A, Monopoli D, Mentado B, Becerra J, Santos-Ruiz L, et al. Dendritic Scaffold onto Titanium Implants. A Versatile Strategy Increasing Biocompatibility. Polymers. 2020 Apr 1;12(4):770http://hdl.handle.net/10668/3530Osseointegration of metal prosthetic implants is a yet unresolved clinical need that depends on the interplay between the implant surface and bone cells. The lack of a relationship between bone cells and metal has traditionally been solved by coating the former with "organic" ceramics, such as hydroxyapatite. A novel approach is hereby presented, immobilizing covalently dendrimeric structures onto titanium implants. Amide-based amino terminal dendrons were synthetized and coupled to titanium surfaces in a versatile and controlled way. The dendritic moieties provide an excellent scaffold for the covalent immobilization of bioactive molecules, such as extracellular matrix (ECM) protein components or antibiotics. Herein, tripeptide arginine-glycine-aspartic acid (RGD) motifs were used to decorate the dendritic scaffolds and their influence on cell adhesion and proliferation processes was evaluated.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Dendritic structuresTitanium implantsTripeptide arginine-glycine-aspartic acid (RGD) recognition patternMaterials testingCell adhesionTitanioOseointegraciónPrótesis e implantesEnsayo de materialesAdhesión celularDendrímerosMedical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Bone Remodeling::Bone Regeneration::OsseointegrationMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Metals::Metals, Light::TitaniumMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Amino Acids::Amino Acids, Acidic::Aspartic AcidMedical Subject Headings::Chemicals and Drugs::Macromolecular Substances::Polymers::DendrimersMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell AdhesionMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Equipment and Supplies::Prostheses and ImplantsMedical Subject Headings::Technology and Food and Beverages::Technology, Industry, and Agriculture::Manufactured Materials::CeramicsMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::OligopeptidesMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell ProliferationMedical Subject Headings::Anatomy::Cells::Cellular Structures::Extracellular Space::Extracellular MatrixMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial AgentsMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Amino Acids::Amino Acids, Basic::ArginineMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Amino Acids::GlycineMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amidesresearch article32244665Acceso abierto10.3390/polym120407702073-4360PMC7240519