Paredes, M DoloresRomecin, PaolaAtucha, Noemi MO'Valle, FranciscoCastillo, JulianOrtiz, M ClaraGarcia-Estañ, Joaquin2023-01-252023-01-252018-04-10Paredes MD, Romecín P, Atucha NM, O'Valle F, Castillo J, Ortiz MC, et al. Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats. Nutrients. 2018 Apr 13;10(4):484.http://hdl.handle.net/10668/12343we have evaluated the antihypertensive effect of several flavonoid extracts in a rat model of arterial hypertension caused by chronic administration (6 weeks) of the nitric oxide synthesis inhibitor, L-NAME. Sprague Dawley rats received L-NAME alone or L-NAME plus flavonoid-rich vegetal extracts (Lemon, Grapefruit + Bitter Orange, and Cocoa) or purified flavonoids (Apigenin and Diosmin) for 6 weeks. L-NAME treatment resulted in a marked elevation of blood pressure, and treatment with Apigenin, Lemon Extract, and Grapefruit + Bitter Orange extracts significantly reduced the elevated blood pressure of these animals. Apigenin and some of these flavonoids also ameliorated nitric oxide-dependent and -independent aortic vasodilation and elevated nitrite urinary excretion. End-organ abnormalities such as cardiac infarcts, hyaline arteriopathy and fibrinoid necrosis in coronary arteries and aorta were improved by these treatments, reducing the end-organ vascular damage. the flavonoids included in this study, specially apigenin, may be used as functional food ingredients with potential therapeutic benefit in arterial hypertension.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/acetylcholineflavonoidsheartkidneynitric oxidephenylephrinesodium balanceAnimalsAntihypertensive AgentsApigeninFlavonoidsHypertensionKidneyMaleNG-Nitroarginine Methyl EsterPlant ExtractsRandom AllocationRatsRats, Sprague-Dawleyresearch article29652818open accessAnimalesAntihipertensivosApigeninaDistribución aleatoriaExtractos vegetalesFlavonoidesHipertensiónNG-Nitroarginina Metil ÉsterRatasRatas Sprague-DawleyRiñón10.3390/nu100404842072-6643PMC5946269https://www.mdpi.com/2072-6643/10/4/484/pdf?version=1525348353https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946269/pdf