Lopez-Perez, DavidRedruello-Romero, AnaïsGarcia-Rubio, JesusArana, CarlosGarcia-Escudero, Luis ATamayo, FranciscoSalmeron, JavierGalvez, JulioLeon, JosefaCarazo, Angel2023-05-032023-05-032022-02-14Lopez-Perez D, Redruello-Romero A, Garcia-Rubio J, Arana C, Garcia-Escudero LA, Tamayo F, et al. In Obese Patients With Type 2 Diabetes, Mast Cells in Omental Adipose Tissue Decrease the Surface Expression of CD45, CD117, CD203c, and FcϵRI. Front Endocrinol (Lausanne). 2022 Mar 15;13:818388.1664-2392http://hdl.handle.net/10668/20558The paradigm of mast cells in type 2 diabetes is changing. Although they were first considered deleterious inflammatory cells, now they seem to be important players driving adipose tissue homeostasis. Here we have employed a flow cytometry-based approach for measuring the surface expression of 4 proteins (CD45, CD117, CD203c, and FcϵRI) on mast cells of omental (o-WAT) and subcutaneous white adipose tissue (s-WAT) in a cohort of 96 patients with morbid obesity. The cohort was split into three groups: non-T2D, pre-T2D, and T2D. Noteworthy, patients with T2D have a mild condition (HbA1cenAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/adipose tissuebariatric surgeryflow cytometrymast cellobesitytype 2 diabetesAdipose TissueDiabetes Mellitus, Type 2HumansLeukocyte Common AntigensMast CellsObesity, MorbidPhosphoric Diester HydrolasesProto-Oncogene Proteins c-kitPyrophosphatasesReceptors, IgEresearch article35370964open accessAntígenos comunes de leucocitoDiabetes Mellitus tipo 2Hidrolasas diéster fosfóricasHumanosMastocitosObesidad mórbidaPirofosfatasasProteínas Proto-oncogénicas c-kitReceptores de IgETejido adiposo10.3389/fendo.2022.818388PMC8965342https://www.frontiersin.org/articles/10.3389/fendo.2022.818388/pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965342/pdf