Margarit, CesarLópez, RafaelAnton, AntonioEscobar, YolandaCasas, AnaCruz, Juan JesúsGalvez, RafaelMañas, AnaZaragozá, Francisco2013-12-112013-12-112012-11-19Margarit C, Juliá J, López R, Anton A, Escobar Y, Casas A, et al. Breakthrough cancer pain - still a challenge. J Pain Res. 2012, 5:559-66http://hdl.handle.net/10668/1420Journal Article;Breakthrough cancer pain is defined as transient pain exacerbation in patients with stable and controlled basal pain. Although variable, the prevalence of breakthrough cancer pain is high (33%-95%). According to the American Pain Foundation, breakthrough pain is observed in 50%-90% of all hospitalized cancer patients, in 89% of all patients admitted to homes for the elderly and terminal-patient care centers, and in 35% of all ambulatory care cancer patients. The management of breakthrough cancer pain should involve an interdisciplinary and multimodal approach. The introduction of new fentanyl formulations has represented a great advance and has notably improved treatment. Among these, the pectin-based intranasal formulation adjusts very well to the profile of breakthrough pain attacks, is effective, has a good toxicity profile, and allows for convenient dosing - affording rapid and effective analgesia with the added advantage of being easily administered by caregivers when patients are unable to collaborate.enPrevalenceManagementDiagnosisOpioidsPrevalenciaDiagnósticoAnalgésicos OpioidesFentaniloPectinasDolor intercurrenteMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Pain::Breakthrough PainMedical Subject Headings::Health CareMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Peripheral Nervous System Agents::Sensory System Agents::Analgesics::Analgesics, OpioidMedical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Piperidines::FentanylMedical Subject Headings::Chemicals and Drugs::Macromolecular Substances::Polymers::Biopolymers::PectinsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosisresearch article23204865open access10.2147/JPR.S364281178-7090PMC3508660