Garcia-Salido, Albertode-Carlos-Vicente, Juan CarlosBelda-Hofheinz, SylviaBalcells-Ramirez, JoanSlocker-Barrio, MariaLeoz-Gordillo, InesHernandez-Yuste, AlexandraGuitart-Pardellans, CarminaCuervas-Mons-Tejedor, MaiteHuidobro-Labarga, BeatrizVazquez Martinez, Jose LuisGutierrez Jimeno, MíriamOulego-Erroz, IgnacioTrastoy-Quintela, JavierMedina-Monzon, CarmenMedina-Ramos, LauraHolanda-Peña, Maria SoledadGil-Anton, JavierSorribes-Orti, ClaraFlores-Gonzalez, Jose CarlosHernandez-Palomo, Rosa MariaSanchez-Ganfornina, InmaFernandez-Romero, EmiliaGarcia-Besteiro, MariaLopez-Herce Cid, JesusGonzalez-Cortes, Rafael2023-02-092023-02-092020-11-26García-Salido A, de Carlos Vicente JC, Belda Hofheinz S, Balcells Ramírez J, Slöcker Barrio M, Leóz Gordillo I, et al. Severe manifestations of SARS-CoV-2 in children and adolescents: from COVID-19 pneumonia to multisystem inflammatory syndrome: a multicentre study in pediatric intensive care units in Spain. Crit Care. 2020 Nov 26;24(1):666http://hdl.handle.net/10668/16674Multisystem inflammatory syndrome temporally associated with COVID-19 (MIS-C) has been described as a novel and often severe presentation of SARS-CoV-2 infection in children. We aimed to describe the characteristics of children admitted to Pediatric Intensive Care Units (PICUs) presenting with MIS-C in comparison with those admitted with SARS-CoV-2 infection with other features such as COVID-19 pneumonia. A multicentric prospective national registry including 47 PICUs was carried out. Data from children admitted with confirmed SARS-CoV-2 infection or fulfilling MIS-C criteria (with or without SARS-CoV-2 PCR confirmation) were collected. Clinical, laboratory and therapeutic features between MIS-C and non-MIS-C patients were compared. Seventy-four children were recruited. Sixty-one percent met MIS-C definition. MIS-C patients were older than non-MIS-C patients (p = 0.002): 9.4 years (IQR 5.5-11.8) vs 3.4 years (IQR 0.4-9.4). A higher proportion of them had no previous medical history of interest (88.2% vs 51.7%, p = 0.005). Non-MIS-C patients presented more frequently with respiratory distress (60.7% vs 13.3%, p  MIS-C seems to be the most frequent presentation among critically ill children with SARS-CoV-2 infection. MIS-C patients are older and usually healthy. They show a higher prevalence of gastrointestinal symptoms and shock and are more likely to receive vasoactive drugs and immunomodulators and less likely to need mechanical ventilation than non-MIS-C patients.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/ChildrenCritical careKawasaki diseasePediatric multisystem inflammatory syndrome temporally associated with COVID-19SARS-CoV-2ShockToxic shock syndromeAdolescentCOVID-19ChildChild, PreschoolFemaleHumansIntensive Care Units, PediatricMalePandemicsPneumonia, ViralProspective StudiesRegistriesSARS-CoV-2SpainSystemic Inflammatory Response Syndromeresearch article33243303open accessReacción en cadena de la polimerasaRespiración artificialEnfermedad críticaNeumoníaFactores inmunológicos10.1186/s13054-020-03332-41466-609XPMC7689392https://ccforum.biomedcentral.com/counter/pdf/10.1186/s13054-020-03332-4https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689392/pdf