Abumayyaleh, MohammadNúñez Gil, Iván JEl-Battrawy, IbrahimEstrada, VicenteBecerra-Muñoz, Víctor ManuelAparisi, AlvaroFernández-Rozas, InmaculadaFeltes, GiselaArroyo-Espliguero, RamónTrabattoni, DanielaLópez-País, JavierPepe, MartinoRomero, RodolfoGarcía, Diego Raúl VillavicencioBiole, CarloalbertoAstrua, Thamar CapelEid, Charbel MarounAlfonso, EmilioFernandez-Presa, LuciaEspejo, CarolinaBuonsenso, DaniloRaposeiras, SergioFernández, CristinaMacaya, CarlosAkin, IbrahimHOPE COVID-19 investigators2023-02-092023-02-092021-03-03http://hdl.handle.net/10668/17371Obesity has been described as a protective factor in cardiovascular and other diseases being expressed as 'obesity paradox'. However, the impact of obesity on clinical outcomes including mortality in COVID-19 has been poorly systematically investigated until now. We aimed to compare clinical outcomes among COVID-19 patients divided into three groups according to the body mass index (BMI). We retrospectively collected data up to May 31st, 2020. 3635 patients were divided into three groups of BMI (30 kg/m2; n = 1061). Demographic, in-hospital complications, and predictors for mortality, respiratory insufficiency, and sepsis were analyzed. The rate of respiratory insufficiency was more recorded in BMI 25-30 kg/m2 as compared to BMI 30 kg/m2 than BMI 30 kg/m2 as compared to BMI 30 kg/m2 as compared to BMI 30 kg/m2 did not impact the mortality rate (HR 1.15, 95% CI: 0.889-1.508; p = 0.27) (HR 1.15, 95% CI: 0.893-1.479; p = 0.27). In multivariate logistic regression analyses for respiratory insufficiency and sepsis, BMI HOPE COVID-19-Registry revealed no evidence of obesity paradox in patients with COVID-19. However, Obesity was associated with a higher rate of respiratory insufficiency and sepsis but was not determined as an independent predictor for a high mortality.enBMICOVID-19Obesity paradoxSARS-CoV-2AdultAgedBody Mass IndexCOVID-19Cause of DeathFemaleHospitalizationHumansLogistic ModelsMaleMiddle AgedObesityProportional Hazards ModelsProtective FactorsRegistriesRespiratory InsufficiencyRetrospective StudiesRisk FactorsSARS-CoV-2Sepsisresearch article33741308open access10.1016/j.orcp.2021.02.0081871-403XPMC7927637https://doi.org/10.1016/j.orcp.2021.02.008https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927637/pdf