Martínez, MiguelGarcía de Viedma, DaríoAlonso, MaríaAndrés, SandraBouza, EmilioCabezas, TeresaCabeza, IsabelReyes, ArmandoSánchez-Yebra, WaldoRodríguez, ManuelSánchez, M IsabelRogado, M CruzFernández, RosaPeñafiel, TeresaMartínez, JuanBarroso, PilarLucerna, M AngelesDíez, L FelipeGutiérrez, Carmelo2015-10-152015-10-152006-08Martínez M, García de Viedma D, Alonso M, Andrés S, Bouza E, Cabezas T, et al. Impact of laboratory cross-contamination on molecular epidemiology studies of tuberculosis. J. Clin. Microbiol. 2006;44(8):2967-90095-1137http://hdl.handle.net/10668/2016Laboratory cross-contamination by Mycobacterium tuberculosis is known to be responsible for the misdiagnosis of tuberculosis, but its impact on other contexts has not been analyzed. We present the findings of a molecular epidemiology analysis in which the recent transmission events identified by a genotyping reference center were overestimated as a result of unnoticed laboratory cross-contamination in the original diagnostic laboratories.enTuberculosisMycobacterium tuberculosisTécnicas de tipificación BacterianaErrores diagnósticosContaminación de equiposMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Clinical Laboratory Techniques::Microbiological Techniques::Bacteriological Techniques::Bacterial Typing TechniquesMedical Subject Headings::Organisms::Bacteria::Gram-Positive Bacteria::Gram-Positive Rods::Gram-Positive Asporogenous Rods::Gram-Positive Asporogenous Rods, Regular::Mycobacteriaceae::Mycobacterium::Mycobacterium tuberculosisMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Actinomycetales Infections::Mycobacterium Infections::TuberculosisMedical Subject Headings::Health Care::Environment and Public Health::Public Health::Equipment ContaminationMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Molecular EpidemiologyMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic ErrorsMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humansresearch article16891518open access10.1128/JCM.00754-061098-660X.PMC1594630