Pathogenic mechanisms involving the interplay between adipose tissue and auto-antibodies in rheumatoid arthritis.

Arias-de la Rosa, IvanEscudero-Contreras, AlejandroRuiz-Ponce, MiriamCuesta-Lopez, LauraRoman-Rodriguez, CristobalPerez-Sanchez, CarlosRuiz-Limon, PatriciaRuiz, Rocio GuzmanLeiva-Cepas, FernandoAlcaide, JuanSegui, PedroPlasencia, ChamaidaMartinez-Feito, AnaFont, PilarAbalos, María COrtega, RafaelaMalagon, Maria MTinahones, Francisco JCollantes-Estevez, EduardoLopez-Pedrera, CharyBarbarroja, Nuria2023-05-032023-05-032022-08-03Arias-de la Rosa I, Escudero-Contreras A, Ruiz-Ponce M, Cuesta-López L, Román-Rodríguez C, Pérez-Sánchez C, et al. Pathogenic mechanisms involving the interplay between adipose tissue and auto-antibodies in rheumatoid arthritis. iScience. 2022 Aug 6;25(9):104893http://hdl.handle.net/10668/22278We aimed to evaluate the association between adipose tissue (AT) dysfunction, autoimmunity, and disease activity in rheumatoid arthritis (RA). A cross-sectional study including 150 RA patients and 50 healthy donors and longitudinal study with 122 RA patients treated with anti-tumor necrosis factor (TNF)-α, anti-interleukin 6 receptor (IL6R) or anti-CD20 therapies for 6 months were carried out. In vitro experiments with human AT and adipocyte and macrophage cell lines were performed. A collagen-induced arthritis mouse model was developed. The insulin resistance and the altered adipocytokine profile were associated with disease activity, the presence of anti-citrullinated proteins anti-bodies (ACPAs), and worse response to therapy in RA. AT in the context of arthritis is characterized by an inflammatory state alongside the infiltration of macrophages and B/plasmatic cells, where ACPAs can have a direct impact, inducing inflammation and insulin resistance in macrophages and promoting a defective adipocyte differentiation, partially restored by biologicals.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Health sciencesImmunologyRheumatologyArthritis, experimentalCross-sectional studiesAutoimmunityBiological productsInsulin resistanceArthritis, rheumatoidAdipocytesPathogenic mechanisms involving the interplay between adipose tissue and auto-antibodies in rheumatoid arthritis.research article36046189open access10.1016/j.isci.2022.1048932589-0042PMC9421387https://doi.org/10.1016/j.isci.2022.104893https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421387/pdf