Martin-Pelaez, SandraSerra-Majem, LluisCano-Ibañez, NaomiMartinez-Gonzalez, Miguel AngelSalas-Salvado, JordiCorella, DoloresLassale, CamilleMartinez, Jose AlfredoAlonso-Gomez, Angel MWärnberg, JuliaVioque, JesusRomaguera, DoraLopez-Miranda, JoseEstruch, RamonTinahones, Francisco JLapetra, JoseFernandez-Aranda, FernandoBueno-Cavanillas, AuroraTur, Josep AMartin, VicentePinto, XavierDelgado-Rodriguez, MiguelMatia, PilarVidal, JosepVazquez, ClotildeDaimiel, LidiaRos, EmiliToledo, EstefaniaNishi, Stephanie KSorli, Jose VMalcampo, MireiaZulet, M AngelesMoreno-Rodriguez, AnaiCueto-Galan, RaquelVivancos-Aparicio, DiegoColom, AntoniGarcia-Rios, AntonioCasas, RosaBernal-Lopez, M RosaSantos-Lozano, Jose ManuelVazquez, ZenaidaGomez-Martinez, CarlosOrtega-Azorin, CarolinaDel Val, Jose LuísAbete, ItziarGoikoetxea-Bahon, AmaiaPascual, ElenaBecerra-Tomas, NereaChillaron, Juan JSanchez-Villegas, Almudena2023-05-032023-05-032022-02-13Martín-Peláez S, Serra-Majem L, Cano-Ibáñez N, Martínez-González MÁ, Salas-Salvadó J, Corella D, et al. Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study. PLoS One. 2022 Apr 13;17(4):e0265079http://hdl.handle.net/10668/20422Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial. Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/AgedCholesterolCross-sectional studiesDepressionDiabetes mellitusFemaleHeart disease risk factorsHumansLongitudinal studiesMaleMetabolic syndromeMiddle agedRandomized controlled trials as topicresearch article35417452open accessEnsayos clínicos controlados aleatorios como asuntoEstudios longitudinalesFactores de riesgo de enfermedad cardiacaSíndrome metabólico10.1371/journal.pone.02650791932-6203PMC9007355https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0265079&type=printablehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007355/pdf