Morales-Munoz, C.Sanchez-Ramos, J. L.Diaz-Lara, M. D.Gonzalez-Gonzalez, J.Gallego-Alonso, I.Hernandez-del-Castillo, M. S.2023-02-122023-02-122017-01-010034-9356http://hdl.handle.net/10668/18871Introduction: Total knee replacement is usually a very painful procedure. A single-dose of femoral nerve block has been shown to provide similar analgesia to an epidural, with fewer side effects, but limited in time.Objective: To compare the analgesia provided by dexamethasone used at perineural level in the femoral nerve block after total knee replacement with the one used at intravenous level, and with that of a control group.Material and methods: A prospective, randomised, double-blind controlled trial was conducted on 81 patients randomly assigned to one of three groups: 1) IV dexamethasone (8 mg); 2) perineural dexamethasone (8 mg), and 3) placebo. All patients received 20ml of ropivacaine 0.5% for femoral nerve block. The primary outcome was the duration of the sensory-analgesic block of the femoral nerve block. The secondary outcomes included pain intensity measurements, patient satisfaction, and incidence of complications.Results: Randomisation was effective. Analgesia duration was significantly higher (PesAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/DexamethasoneFemoral nerve blockPostoperative analgesiaTotal knee replacementBrachial-plexus blockadePeripheral-nerveAdjuvant dexamethasoneInterscalene blockRandomized-trialsIn-vitroBupivacaineDurationMetaanalysisRopivacaineresearch articleopen access10.1016/j.redar.2016.05.0062340-3284http://rabida.uhu.es/dspace/bitstream/10272/12811/2/Eficacia_analgesica.pdf449604100005