Gallego-Durán, RocíoCerro-Salido, PabloGomez-Gonzalez, EmilioPareja, María JesúsAmpuero, JavierRico, María CarmenAznar, RafaelVilar-Gomez, EduardoBugianesi, ElisabettaCrespo, JavierGonzález-Sánchez, Francisco JoséAparcero, ReyesMoreno, InmaculadaSoto, SusanaArias-Loste, María TeresaAbad, JavierRanchal, IsidoraAndrade, Raúl JesúsCalleja, Jose LuisPastrana, MiguelLo Iacono, OresteRomero-Gómez, Manuel2016-09-222016-09-222016-08-12Gallego-Durán R, Cerro-Salido P, Gomez-Gonzalez E, Pareja MJ, Ampuero J, Rico MC, et al. Imaging biomarkers for steatohepatitis and fibrosis detection in non-alcoholic fatty liver disease. Sci Rep. 2016; 6:31421http://hdl.handle.net/10668/2426Journal Article;There is a need, in NAFLD management, to develop non-invasive methods to detect steatohepatitis (NASH) and to predict advanced fibrosis stages. We evaluated a tool based on optical analysis of liver magnetic resonance images (MRI) as biomarkers for NASH and fibrosis detection by investigating patients with biopsy-proven NAFLD who underwent magnetic resonance (MR) protocols using 1.5T General Electric (GE) or Philips devices. Two imaging biomarkers (NASHMRI and FibroMRI) were developed, standardised and validated using area under the receiver operating characteristic curve (AUROC) analysis. The results indicated NASHMRI diagnostic accuracy for steatohepatitis detection was 0.83 (95% CI: 0.73-0.93) and FibroMRI diagnostic accuracy for significant fibrosis determination was 0.85 (95% CI: 0.77-0.94). These findings were independent of the MR system used. We conclude that optical analysis of MRI has high potential to define non-invasive imaging biomarkers for the detection of steatohepatitis (NASHMRI) and the prediction of significant fibrosis (FibroMRI) in NAFLD patients.enÁrea bajo la curvaBiopsiaEspectroscopía de resonancia magnéticaCurva ROCBiomarcadoresEsteatosis hepática no alcohólicaMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Area Under CurveMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytodiagnosis::BiopsyMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Spectrum Analysis::Magnetic Resonance SpectroscopyMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Sensitivity and Specificity::ROC CurveMedical Subject Headings::Chemicals and Drugs::Biological Factors::BiomarkersMedical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Fatty Liver::Non-alcoholic Fatty Liver Diseaseresearch article27514671open access10.1038/srep314212045-2322PMC4981860