Angarita Davila, LisseBermudez, ValmoreAparicio, DanielCespedes, VirginiaEscobar, Ma CristinaDuran-Agüero, SamuelCisternas, Silvanade Assis Costa, JorgeRojas-Gomez, DianaReyna, NadiaLopez-Miranda, Jose2023-01-252023-01-252019-06-24Angarita Dávila L, Bermúdez V, Aparicio D, Céspedes V, Escobar MC, Durán-Agüero S, et al. Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study. Nutrients. 2019 Jun 28;11(7):1477http://hdl.handle.net/10668/14202Oral diabetes-specific nutritional supplements (ONS-D) induce favourable postprandial responses in subjects with type 2 diabetes (DM2), but they have not been correlated yet with incretin release and subjective appetite (SA). This randomised, double-blind, cross-over study compared postprandial effects of ONS-D with isomaltulose and sucromalt versus standard formula (ET) on glycaemic index (GI), insulin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1) and SA in 16 individuals with DM2. After overnight fasting, subjects consumed a portion of supplements containing 25 g of carbohydrates or reference food. Blood samples were collected at baseline and at 30, 60, 90, 120, 150 and 180 min; and SA sensations were assessed by a visual analogue scale on separate days. Glycaemic index values were low for ONS-D and intermediate for ET (p< 0.001). The insulin area under the curve (AUC0–180 min) (p < 0.02) and GIP AUC (p < 0.02) were lower after ONS-D and higher GLP-1 AUC when compared with ET (p < 0.05). Subjective appetite AUC was greater after ET than ONS-D (p < 0.05). Interactions between hormones, hunger, fullness and GI were found, but not within the ratings of SA; isomaltulose and sucromalt may have influenced these factors.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Glycaemic indexIncretinsIsomaltuloseNutritional supplementSubjective appetiteSucromaltAdministration, oralAppetite regulationBiomarkersBlood glucoseCross-over studiesDiabetes mellitus, type 2Dietary supplementsDisaccharidesDouble-blind methodFemaleFructoseGastric inhibitory polypeptideGlucagon-like peptide 1Glycemic indexHumansInsulinIsomaltoseMaleMiddle agedPeptide hormonesTime factorsTreatment outcomeresearch article31261732open accessAdministración oralDiabetes mellitus tipo 2DisacáridosEstudios cruzadosFructosaGlucemiaHormonas peptídicasInsulinaIsomaltosa10.3390/nu110714772072-6643PMC6683048https://res.mdpi.com/d_attachment/nutrients/nutrients-11-01477/article_deploy/nutrients-11-01477-v2.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683048/pdf