Panagides, VassiliDel Val, DavidAbdel-Wahab, MohamedMangner, NormanDurand, EricIhlemann, NikolajUrena, MarinaPellegrini, CostanzaGiannini, FrancescoGasior, TomaszWojakowski, WojtekLandt, MartinAuffret, VincentSinning, Jan MalteCheema, Asim NNombela-Franco, LuisChamandi, ChekrallahCampelo-Parada, FranciscoMunoz-Garcia, ErikaHerrmann, Howard CTesta, LucaKim, Won KeunCastillo, Juan CarlosAlperi, AlbertoTchetche, DidierBartorelli, Antonio LKapadia, SamirStortecky, StefanAmat-Santos, IgnacioWijeysundera, Harindra CLisko, JohnGutiérrez-Ibanes, EnriqueSerra, VicençSalido, LuisaAlkhodair, AbdullahLivi, UgolinoChakravarty, TarunLerakis, StamatiosVilalta, VictoriaRegueiro, AnderRomaguera, RafaelKappert, UtzBarbanti, MarcoMasson, Jean BernardMaes, FrédéricFiorina, ClaudiaMiceli, AntonioKodali, SusheelRibeiro, Henrique BMangione, Jose ArmandoSandoli de Brito, FabioActis Dato, Guglielmo MarioRosato, FrancescoFerreira, Maria CristinaCorreia de Lima, ValterColafranceschi, Alexandre SicilianoAbizaid, AlexandreMarino, Marcos AntonioEsteves, ViniciusAndrea, JulioGodinho, Roger RAlfonso, FernandoEltchaninoff, HeleneSøndergaard, LarsHimbert, DominiqueHusser, OliverLatib, AzeemLe Breton, HervéServoz, ClementPascual, IsaacSiddiqui, SaifOlivares, PaoloHernandez-Antolin, RosanaWebb, John GSponga, SandroMakkar, RajKini, Annapoorna SBoukhris, MarouaneGervais, PhilippeLinke, AxelCrusius, LisaHolzhey, DavidRodés-Cabau, Josep2023-05-032023-05-032022http://hdl.handle.net/10668/19736Infective endocarditis (IE) following transcatheter aortic valve replacement (TAVR) has been associated with a dismal prognosis. However, scarce data exist on IE perivalvular extension (PEE) in such patients. This multicenter study included 579 patients who had the diagnosis of definite IE at a median of 171 (53-421) days following TAVR. PEE was defined as the presence of an intracardiac abscess, pseudoaneurysm, or fistula. A total of 105 patients (18.1%) were diagnosed with PEE (perivalvular abscess, pseudoaneurysm, fistula, or a combination in 87, 7, 7, and 4 patients, respectively). A history of chronic kidney disease (adjusted odds ratio [ORadj], 2.08; 95% confidence interval [CI]: 1.27-3.41; P = .003) and IE secondary to coagulase-negative staphylococci (ORadj, 2.71; 95% CI: 1.57-4.69; P  PEE occurred in about one-fifth of IE post-TAVR patients, with the presence of coagulase-negative staphylococci and chronic kidney disease determining an increased risk. Patients with PEE-IE exhibited high early and late mortality rates, and surgery during IE hospitalization seemed to be associated with better outcomes.enTAVITAVRheart surgeryinfective endocarditisAbscessAneurysm, FalseCoagulaseEndocarditisEndocarditis, BacterialHumansRenal Insufficiency, ChronicRisk FactorsTranscatheter Aortic Valve Replacementresearch article34894124open access10.1093/cid/ciab10041537-6591https://boris.unibe.ch/163285/1/Perivalvular.pdf